公开(公告)号：US20220268790A1

公开(公告)日：2022-08-25

申请号：US17730484

申请日：2022-04-27

Applicant: AJINOMOTO CO., INC.

Inventor： Sachise KARAKAWA ,  Tomoyuki TAGAMI ,  Rumi NISHIMOTO ,  Shinya KIKUCHI ,  Akira IMAIZUMI ,  Koichi AZUMA ,  Tomoaki HOSHINO ,  Takaaki TOKITO ,  Hidenobu ISHII ,  Norikazu MATSUO

IPC: G01N33/94 ,  G01N33/68 ,  G16H10/40 ,  G16H50/30

Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.

公开(公告)号：US20210287802A1

公开(公告)日：2021-09-16

申请号：US17307644

申请日：2021-05-04

Applicant: Ajinomoto Co., Inc.

Inventor： Nobukazu ONO ,  Atsuko SHINHARA ,  Takahiko MURAMATSU ,  Shinya KIKUCHI ,  Hiroshi YAMAMOTO ,  Koichi SHIRAISHI ,  Kazuhiro KATAYAMA ,  Nobuyasu FUKUTAKE ,  Masahiko HIGASHIYAMA ,  Shinichi OHKAWA ,  Makoto UENO ,  Yohei MIYAGI ,  Naoyuki OKAMOTO

IPC: G16H50/20 ,  G01N33/574 ,  G01N33/68 ,  G16B99/00 ,  G16B20/00

Abstract: A method of evaluating pancreatic cancer includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated, and (II) an evaluating step of evaluating a state of pancreatic cancer in the subject by calculating a value of a formula using the amino acid concentration data of the subject obtained at the obtaining step and the formula previously established for evaluating the state of pancreatic cancer, including an explanatory variable to be substituted with the concentration value of the amino acid. The amino acid concentration data includes the concentration values of at least two amino acids of Asn, His, Thr, Ala, Cit, Arg, Tyr, Val, Met, Lys, Trp, Gly, Pro, Orn, Ile, Leu, Phe, Ser, and Gln, and the formula includes at least two explanatory variables to be substituted with the concentration values of at least two amino acids of Asn, His, Thr, Ala, Cit, Arg, Tyr, Val, Met, Lys, Trp, Gly, Pro, Orn, Ile, Leu, Phe, Ser, and Gln.