公开(公告)号：US09939451B2

公开(公告)日：2018-04-10

申请号：US14766759

申请日：2013-08-30

Applicant: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION

Inventor： Byung Gon Kim ,  Jun Young Choi

IPC: G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  A61K38/08 ,  C12Q1/68 ,  A61K38/14 ,  A61K31/716 ,  A61K31/739

CPC classification number: G01N33/6896 ,  A61K31/716 ,  A61K31/739 ,  A61K38/08 ,  A61K38/14 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2800/2871

Abstract: The present invention relates to a biomarker composition for detecting white matter stroke, the biomarker composition containing a toll-like receptor 2 (TLR2), and a medical use using the TLR2. The TLR2 can be used as a biomarker for white matter stroke by defending against ischemic demyelination and oligodendrocyte death, and when targeting the TLR2, ischemic white matter stroke can be treated or prevented.