公开(公告)号：US20210290825A1

公开(公告)日：2021-09-23

申请号：US17053429

申请日：2019-06-25

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Moon Suk KIM ,  Seung Hun Park ,  Hyeon Jin JU

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/56 ,  A61L27/54

摘要： The present invention relates to an injection formulation composition for use as a filler or a drug carrier through a click chemistry reaction. More specifically, the present invention relates to an injection formulation composition comprising: a first liquid comprising a first biopolymer having a first click chemistry functional group introduced thereinto; and a second liquid comprising a second biopolymer having a second click chemistry functional group introduced thereinto, wherein the first click chemistry functional group is chemically linkable with the second click chemistry functional group, to a method for preparing an injection formulation hydrogel using the composition, and to a medical filler, an in-vivo injection type supporter, or a drug carrier using the composition.

公开(公告)号：US20200299330A1

公开(公告)日：2020-09-24

申请号：US16858071

申请日：2020-04-24

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Moon Suk KIM ,  Sang Dun CHOI ,  Seung Hun PARK ,  Masaud SHAH

IPC分类号： C07K7/06 ,  A61P17/02

摘要： A substance P analog having a progenitor cell or stem cell recruiting activity and a method of recruiting progenitor cells or stem cells using the substance P analog are disclosed. The substance P analog has an effect of recruiting endogenous progenitor cells or stem cells to a wound or disease-occurring site. Thus, the disclosure also describes its use in recruiting progenitor cells or stem cells and a method of regenerating or treating a damaged organ or tissue, or a method of healing a wound.

公开(公告)号：US20220409775A1

公开(公告)日：2022-12-29

申请号：US17778809

申请日：2020-11-17

申请人： Ajou University Industry-Academic Cooperation Foundation

发明人： Moon Suk KIM ,  Seung Hun PARK

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54

摘要： The present invention relates to an injectable hydrogel composition having the recruitment of endogenous progenitors or stem cells and the induction of vascular differentiation of recruited cells, and more specifically to an injectable hydrogel composition having the recruitment of endogenous progenitors or stem cells and the induction of vascular differentiation of recruited cells, which consists of: a first solution including anionic hyaluronic acid into which a vascular differentiation inducing factor is introduced; and a second solution including a cationic material, wherein a stem cell recruitment factor is further included in the first solution and/or the second solution, and wherein a hydrogel is formed by electrostatic interaction.
In the hydrogel composition of the present invention, it was confirmed that the stem cell recruitment factor was released from the injected hydrogel, and endogenous progenitor cells/stem cells were recruited in the hydrogel, and the induction of angiogenesis was promoted by differentiating into vascular cells by the vascular differentiation inducing factor chemically introduced into hyaluronic acid. In particular, it was confirmed that when the vascular differentiation inducing factor was chemically introduced into hyaluronic acid, a high angiogenesis-inducing effect was observed. Therefore, the hydrogel composition of the present invention has excellent recruitment of endogenous progenitor cells/stem cells and induction of vascular differentiation, and thus, it can be effectively applied to various tissue regenerations and wound treatments in addition to the formation of blood vessels.

公开(公告)号：US20180215934A1

公开(公告)日：2018-08-02

申请号：US15739628

申请日：2016-06-27

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Kyung Sook KIM ,  Da Yeon KIM ,  Seung Hun PARK ,  Ja Yong JANG ,  Moon Suk KIM

IPC分类号： C09D11/14 ,  A61L27/26 ,  A61L27/38 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  C09D11/102 ,  A61L31/04 ,  A61L31/16

CPC分类号： C09D11/14 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3834 ,  A61L31/041 ,  A61L31/16 ,  A61L2300/424 ,  C09D11/08 ,  C09D11/102 ,  C09D11/30 ,  C09D101/286 ,  C09D105/04 ,  C09D105/08 ,  C12N5/0062 ,  C12N5/0068

摘要： The present invention provides a two-component bioink including a first solution and a second solution separately, wherein (i) the first solution includes a first biopolymer to which a first chemical functional group is introduced, and the second solution includes a second biopolymer to which a second chemical functional group able to chemically bond with the first chemical functional group is introduced; or (ii) the first solution includes a third biopolymer having a first electrostatic functional group, and the second solution includes a fourth biopolymer having a second electrostatic functional group able to physically bond with the first electrostatic functional group, a 3D biomaterial including the same, and a method for preparing the same.