公开(公告)号：US20200022954A1

公开(公告)日：2020-01-23

申请号：US16488881

申请日：2018-03-09

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon CHOUNG ,  Yun Yeong LEE ,  Oak-Sung CHOO

IPC: A61K31/40 ,  A61K9/28 ,  A61P27/16

Abstract: The present invention relates to a composition for preventing or treating hearing loss, containing an HMG-CoA reductase inhibitor and, more specifically, to a composition for preventing or treating diabetes-mediated hearing loss, containing, as an active ingredient(s), one or more types selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. A pharmaceutical composition containing an HMG-CoA reductase inhibitor, according to the present invention, inhibits auditory cell death caused by diabetes, and thus is very useful as an agent for preventing or treating diabetes-mediated sensorineural hearing loss.

公开(公告)号：US20240009349A1

公开(公告)日：2024-01-11

申请号：US18370878

申请日：2023-09-21

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon CHOUNG ,  Jong Hoon CHUNG ,  Hoon SEONWOO ,  Kyoung-Je JANG ,  Beomyong SHIN

IPC: A61L27/18 ,  A61L27/54 ,  C08G63/08 ,  D01D5/00

CPC classification number: A61L27/18 ,  A61L27/54 ,  C08G63/08 ,  D01D5/003 ,  A61F2/18

Abstract: Disclosed is a method of treating a chronic tympanic perforation with a PCL patch tissue regeneration scaffold comprising preparing solution by adding polycaprolactone (PCL) and an acid to an organic solvent; preparing an electrospinning solution by adding a growth factor to the solution and stirring; collecting nanofibers arranged in a spindle shape on a collector by connecting the electrospinning solution prepared to a syringe pump and operating the electrospinning device; and administering the PCL patch tissue regeneration scaffold to a subject.

公开(公告)号：US20220133832A1

公开(公告)日：2022-05-05

申请号：US17429543

申请日：2020-02-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon CHOUNG

IPC: A61K36/87 ,  A61P27/16 ,  A23L33/00 ,  A23L33/105

Abstract: A composition containing a Vitis vinifera leaf extract as an active ingredient and its uses in preventing or treating tinnitus are disclosed. The composition may be a pharmaceutical composition or a food composition. The composition containing a Vitis vinifera leaf extract as an active ingredient is excellent in alleviating and improving tinnitus caused by noise and the like, and therefore is very useful as a composition for preventing or treating tinnitus.

公开(公告)号：US20210299084A1

公开(公告)日：2021-09-30

申请号：US17265436

申请日：2019-08-06

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon CHOUNG ,  Yeon Ju KIM

IPC: A61K31/352 ,  A61K31/202 ,  A61P27/16 ,  A61K45/06

Abstract: A pharmaceutical composition containing forskolin and retinoic acid as active ingredients which is suitable for preventing or treating sensorineural hearing loss is disclosed. A pharmaceutical composition containing forskolin and retinoic acid as active ingredients has an excellent effect of preventing, alleviating or treating hearing loss caused by ototoxic drugs during anticancer treatment, and thus is useful as a pharmaceutical composite preparation capable of reducing side effects of anticancer drugs and, additionally, as an agent for preventing or treating sensorineural hearing loss.