公开(公告)号：US11667710B2

公开(公告)日：2023-06-06

申请号：US17016744

申请日：2020-09-10

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  G01N33/577 ,  G01N33/574 ,  A61P31/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574 ,  G01N33/577

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10676525B2

公开(公告)日：2020-06-09

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina Schwabe ,  Eric Brown ,  Philip Kong ,  Ilaria Tassi ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Robert Pejchal ,  Nels P. Nielson

IPC: C07K16/28 ,  A61P25/28 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10590198B2

公开(公告)日：2020-03-17

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Francesca Avogadri-Connors ,  William Monteith

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00 ,  A61P37/02 ,  A61P25/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250092131A1

公开(公告)日：2025-03-20

申请号：US18824619

申请日：2024-09-04

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12227568B2

公开(公告)日：2025-02-18

申请号：US16972840

申请日：2019-06-07

Applicant: Alector LLC

Inventor： Patricia Culp ,  Seung-Joo Lee ,  Helen Lam ,  Wei-Hsien Ho ,  Arnon Rosenthal

IPC: C07K16/00 ,  C07K16/28 ,  C12P21/08 ,  C07K1/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11470827B2

公开(公告)日：2022-10-18

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07H21/04 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.

公开(公告)号：US11254743B2

公开(公告)日：2022-02-22

申请号：US16869315

申请日：2020-05-07

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11136390B2

公开(公告)日：2021-10-05

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee ,  William Monteith ,  Herve Rhinn ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190040131A1

公开(公告)日：2019-02-07

申请号：US16054840

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Patricia Culp ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Nels P. Nielson ,  Robert Pejchal

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250144209A1

公开(公告)日：2025-05-08

申请号：US19014653

申请日：2025-01-09

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.