公开(公告)号：US20240174746A1

公开(公告)日：2024-05-30

申请号：US18551162

申请日：2022-03-17

Applicant: ALECTOR LLC

Inventor： Eric BROWN ,  Angie Grace YEE ,  Tina SCHWABE ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200339680A1

公开(公告)日：2020-10-29

申请号：US16959081

申请日：2018-12-21

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Eric BROWN ,  Tina SCHWABE ,  Angie YEE ,  Herve RHINN

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240166738A1

公开(公告)日：2024-05-23

申请号：US18551963

申请日：2022-03-23

Applicant: ALECTOR LLC

Inventor： Herve RHINN ,  Eric BROWN

IPC: C07K16/28 ,  A61P31/14

CPC classification number: C07K16/28 ,  A61P31/14

Abstract: The present disclosure is generally directed to uses of antibodies that bind to a TMEM106B protein in treating, preventing, or reducing the risk of coronavirus (e.g., SARS-COV-2) infection.

公开(公告)号：US20200317776A1

公开(公告)日：2020-10-08

申请号：US16835140

申请日：2020-03-30

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190040130A1

公开(公告)日：2019-02-07

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  IIaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240383997A1

公开(公告)日：2024-11-21

申请号：US18621575

申请日：2024-03-29

Applicant: ALECTOR LLC

Inventor： Eric BROWN ,  Hamid SALIMI ,  Wei-Hsien HO ,  Leonard PRESTA ,  Margaret TANG ,  Jeonghoon SUN

IPC: C07K16/28 ,  A61K49/00 ,  C07K16/18 ,  G01N33/50

Abstract: Provided herein are engineered constant domains that have been engineered to comprise a blood brain barrier (BBB)-binding region, such a CDRH3 from an antibody that binds to a blood brain barrier target. Such engineered constant domains can be within a full length antibody or an antigen-binding fragment of an antibody such that the antibody or fragment is capable of binding to both the antigen of the antibody or fragment and the BBB target and is capable of being transported across the BBB.

公开(公告)号：US20230312712A1

公开(公告)日：2023-10-05

申请号：US18174499

申请日：2023-02-24

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  C07K2317/71 ,  C07K2317/90 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2039/505

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230303681A1

公开(公告)日：2023-09-28

申请号：US17820686

申请日：2022-08-18

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Eric BROWN ,  Tina SCHWABE ,  Angie YEE ,  Herve RHINN

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K2317/34 ,  C07K2317/56

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.