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公开(公告)号：US20230065527A1
公开(公告)日：2023-03-02
申请号：US17444947
申请日：2021-08-12
发明人： Tongfei Wu , Pierre Jean-Marie Bernard Raboisson , Francois Gonzalvez , Antitsa Dimitrova Stoycheva , Jerome Deval , Cheng Liu , Qingling Zhang
IPC分类号： C07D487/10 , C07D519/00 , C07D401/14 , C07D491/107 , C07D491/048 , C07D471/04
摘要： The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.
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公开(公告)号：US20200317686A1
公开(公告)日：2020-10-08
申请号：US16836132
申请日：2020-03-31
发明人： Koen Vandyck , Pierre Jean-Marie Bernard Raboisson , Jerome Deval , Leonid Beigelman , David McGowan , Yannick Debing
IPC分类号： C07D495/04 , A61P35/00 , C07D513/04 , C07D487/04 , C07D519/00
摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230002413A1
公开(公告)日：2023-01-05
申请号：US17303089
申请日：2021-05-19
发明人： Tongfei Wu , Pierre Jean-Marie Bernard Raboisson , Antitsa Dimitrova Stoycheva , Francois Gonzalvez , Jerome Deval , Cheng Liu
IPC分类号： C07D519/00 , C07C229/16 , C07C215/14 , C07C233/36 , C07D207/267 , C07D295/135 , C07D217/02 , C07D209/44 , C07C211/42 , C07D205/12 , C07D491/107 , C07D217/04 , C07D401/14 , C07D471/04
摘要： The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.
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公开(公告)号：US20220143032A1
公开(公告)日：2022-05-12
申请号：US17520173
申请日：2021-11-05
发明人： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC分类号： A61K31/53 , A61K45/06 , C07D401/12 , C07D413/12 , A61K31/4439 , C07D471/04 , C07D401/14 , A61P1/16 , A61P3/04
摘要： Disclosed herein are compounds of Formula I″: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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公开(公告)号：US11198699B2
公开(公告)日：2021-12-14
申请号：US16836132
申请日：2020-03-31
发明人： Koen Vandyck , Pierre Jean-Marie Bernard Raboisson , Jerome Deval , Leonid Beigelman , David McGowan , Yannick Debing
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , C07D487/04 , C07D473/34 , A61K31/53 , A61K31/52 , A61K31/519 , A61K31/522 , C07D473/30 , A61K31/437 , A61P35/00 , C07D473/26 , C07D471/04 , C07K16/22
摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210355112A1
公开(公告)日：2021-11-18
申请号：US17330232
申请日：2021-05-25
IPC分类号： C07D403/14 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要： Disclosed herein are compounds of Formula I: TL-La-CE-HD (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
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公开(公告)号：US11091467B2
公开(公告)日：2021-08-17
申请号：US16869211
申请日：2020-05-07
IPC分类号： C07D471/04 , C07D403/14 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D487/04
摘要： Disclosed herein are compounds of Formula I: TL-La-CE-HD (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
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公开(公告)号：US20240352464A1
公开(公告)日：2024-10-24
申请号：US18599052
申请日：2024-03-07
发明人： Leonid Beigelman , Vivek Kumar Rajwanshi , Xuan Luong , Kellan Passow , Aneerban Bhattacharya , Saul Martinez Montero , Jerome Deval
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12Y101/01062 , C12N2310/14
摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising additional modification including a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap. The siNA molecules may reduce or inhibit the production of hydroxysteroid dehydrogenase.
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公开(公告)号：US11858913B2
公开(公告)日：2024-01-02
申请号：US17520176
申请日：2021-11-05
发明人： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC分类号： C07D401/14 , C07D403/12
CPC分类号： C07D403/12 , C07D401/14
摘要： Disclosed herein are compounds of Formula I:
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.-
公开(公告)号：US11786532B2
公开(公告)日：2023-10-17
申请号：US17520173
申请日：2021-11-05
发明人： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC分类号： A61K31/53 , A61P1/16 , A61P3/04 , A61K31/4439 , A61K45/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04
CPC分类号： A61K31/53 , A61K31/4439 , A61K45/06 , A61P1/16 , A61P3/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04
摘要： Disclosed herein are compounds of Formula I″:
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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