公开(公告)号：US3849557A

公开(公告)日：1974-11-19

申请号：US31226172

申请日：1972-12-05

申请人： ALLEN & HANBURYS LTD

发明人： JACK D ,  GLOVER E

IPC分类号： C07D235/22 ,  C07D519/00 ,  A61K27/00

CPC分类号： C07D235/22 ,  Y10S514/906

摘要： 1. AN INJECTABLE COMPOSITION IN DOSAGE UNIT FORM COMPRISING AS ACTIVE INGREDIENT A COMPOUND OF THE FORMULA:

1-R4,2-R3,3-(1-R4,2-R3,4-R1,5-R2-IMIDAZOL-3-YLIUM-N=N-),

4-R1,5-R2-IMIDAZOLIUM 2X(-)

WHEREIN: R1 AND R2, WHICH ARE THE SAME OR DIFFERENT, ARE EACH HYDROGEN, LOWER ALKYL, HALOGEN, PHENYL, PHENYL SUBSTITUTED BY HALOGEN, PHENYL SUBSTITUTED BY HYDROXY, PHENYL SUBSTITUTED BY LOWER ALKOXY, PHENYL SUBSTITUTED BY TRIFLUOROMETHYL, PHENYL SUBSTITUTED BY NITRO; OR TOGETHER WITH THE ADJACENT CARBON ATOMS TO WHICH THEY ARE ATTACHED FORM PHENYL; R3 AND R4, WHICH ARE THE SAME OR DIFFERENT, ARE EACH LOWER ALKYL OR PHENYL, OR TOGETHER WITH THE ADJACENT NITROGEN ATOM FORM PYRIDINIUM OR TETRAHYDROPYRIDINIUM; AND X IS A PHYSIOLOGICALLY ACCEPTABLE ANION, IN ASSOCIATION WITH A PHARMACEUTICALLY ACCEPTABLE CARRIER, WHEREIN EACH DOSAGE UNIT CONTAINS FROM 2 TO 100 MGS. OF ACTIVE INGREDIENT.

公开(公告)号：US3773746A

公开(公告)日：1973-11-20

申请号：US3773746D

申请日：1971-05-13

申请人： ALLEN & HANBURYS LTD

发明人： JACK D ,  GLOVER E

IPC分类号： C07D213/77 ,  C07D233/54 ,  C07D235/22 ,  C07D471/04 ,  C07D519/00 ,  C07C115/00

CPC分类号： C07D213/77 ,  C07C243/00 ,  C07D233/54 ,  C07D235/22 ,  C07D471/04

摘要： THERE ARE PROVIDED COMPOUNDS OF THE GENERAL FORMULA

(2-R3,3-R4,4-R2,5-R1-1H-IMIDAZOL-1-YL)2-N2 (X(-))2

IN WHICH R1-R4 WHICH MAY BE THE SAME OR DIFFERENT REPRESENT LOWER ALKYL, LOWER ALKENYL, HALOGEN, ARALKYL OR ARYL IN WHICH THE ARYL GROUP MAY BE SUBSTITUTED WITH HYDROXY, LOWER ALKOXY, HALOGEN, NITRO OR TRIFLUOROMETHYL AND IN WHICH ANY TWO ADJACENT GROUPS R MAY TOGETHER WITH 2 ATOMS OF THE IMIDAZOLE RING FORM A 5, 6 OR 7 MEMBERED CARBOCYCLIC OR HETEROCYCLIC RING; AND X REPRESENTS A PHYSIOLOGICALLY ACCEPTABLE ANION. THESE COMPOUNDS HAVE A CURARE LIKE NEUROMUSCULAR BLOCKING ACTION.