专利检索 ap:("ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA") AND inv:"Laura Menotti" 第 1 页

1.

发明授权
Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof 有权

公开(公告)号：US09744199B2

公开(公告)日：2017-08-29

申请号：US14864098

申请日：2015-09-24

申请人： ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA

发明人： Gabriella Campadelli , Laura Menotti

IPC分类号： A61K35/00 , A61K35/76 , A61K49/04 , C07K14/005 , C12N7/00 , A61K39/245 , C07K14/035 , A61K35/763

CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407

摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.