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    3 4-dihydroacridin-2-(1h)-one derivatives
    2.
    发明授权
    3 4-dihydroacridin-2-(1h)-one derivatives 失效
    3 4-二氢吡啶-2-（1H） - 酮衍生物

    公开(公告)号：US3649632A

    公开(公告)日：1972-03-14

    申请号：US3649632D

    申请日：1970-01-27

    Applicant: AMERICAN HOME PROD

    Inventor： DIEBOLD JAMES L ,  WOLF MILTON

    IPC: C07D219/06 ,  C07D37/18

    CPC classification number: C07D219/06

    Abstract: THE DISCLOSURE IS DIRECTED TO NOVEL 3,4-DIHYDROACRIDIN2(1H)-ONE DERIVATIVES OBTAINED BY THE REACTION OF OAMINOCARBONYL DERIVATIVES WITH CYCLOHEXANE-1,4-DIONE IN THE PRESENCE OF A STRONG ACID. THE COMPOUNDS ARE USEFUL AS CENTRAL NERVOUS SYSTEM DEPRESSANTS IN THAT THEY PRODUCE A CALMING EFFECT IN THE HOST.

    Ortho-mercaptoaroylamides and salts thereof as hypoglycemic agents
    4.
    发明授权
    Ortho-mercaptoaroylamides and salts thereof as hypoglycemic agents 失效
    正硫代酰胺酰胺及其盐作为降血糖剂

    公开(公告)号：US3928590A

    公开(公告)日：1975-12-23

    申请号：US47712174

    申请日：1974-06-06

    Applicant: AMERICAN HOME PROD

    Inventor： WOLF MILTON ,  SELLSTEDT JOHN H ,  FENICHEL RICHARD L

    IPC: A61K31/40 ,  C07D295/04 ,  C07D295/10 ,  A61K27/00

    CPC classification number: C07D295/10 ,  A61K31/40 ,  C07D295/04 ,  Y10S514/866

    Abstract: Ortho-mercaptoaroylamides and pharmaceutically acceptable salts thereof exhibit hypoglycemic activity in warm-blooded animals. The compounds may be prepared directly by the reaction of a secondary amine with a 2-imino-1,3-benzothiazin-4-one or indirectly by the reaction of the desired amine with (ochlorocarbonylphenyl) dithioether followed by reduction of the disulfide linkage.

    Abstract translation: 正 - 巯基酰基酰胺及其药学上可接受的盐在温血动物中表现出低血糖活性。 可以通过仲胺与2-亚氨基-1,3-苯并噻嗪-4-酮的反应或间接通过所需胺与（邻 - 氯羰基苯基）二硫醚的反应直接制备化合物，然后还原二硫化物 连锁。

    2-amido-6-amino penicillanic acids and related compounds
    5.
    发明授权
    2-amido-6-amino penicillanic acids and related compounds 失效
    2-氨基-6-氨基苯胺酸及相关化合物

    公开(公告)号：US3669980A

    公开(公告)日：1972-06-13

    申请号：US3669980D

    申请日：1969-07-22

    Applicant: AMERICAN HOME PROD

    Inventor： BOGASH RICHARD ,  WOLF MILTON ,  SELLSTEDT JOHN H

    IPC: C07D499/00 ,  C07D499/42 ,  C07D99/16 ,  C07D99/24

    CPC classification number: C07D499/00

    Abstract: This invention concerns 2-amido-6-aminopenicillanic acids, 2amido-6-haloimidopenicillins, 2-amido-6-alkoxyimidopenicillins, 2-amido-7-amino-cephalosporanic acids, 2-amido-7-haloimidocephalosporins and 2-amido-7-alkoxyimido-cephalosporins which are useful as intermediates in the preparation of synthetic penicillins and cephalosporins having potent antibiotic activity. Further, it relates to a process for the preparation of these intermediates from penicillins and cephalosporins. Still further, it concerns the preparation of 6-aminopenicillanic acid and 7aminocephalosporanic acid by the respective hydrolysis of 2amido-6-aminopenicillanic acids and 2-amido-7aminocephalosporanic acids.

    Abstract translation: 本发明涉及2-氨基-6-氨基青霉烷酸，2-氨基-6-卤代亚氨基青霉素，2-氨基-6-烷氧基亚氨基青霉素，2-氨基-7-氨基 - 头孢菌素酸，2-氨基-7-卤代亚氨基 - 头孢菌素和2 - 氨基-7-烷氧基亚氨基 - 头孢菌素，其可用作制备具有有效抗生素活性的合成青霉素和头孢菌素的中间体。 此外，它涉及从青霉素和头孢菌素制备这些中间体的方法。 此外，它涉及通过2-氨基-6-氨基青霉烷酸和2-酰氨基-7-氨基头孢烷酸的相应水解制备6-氨基青霉烷酸和7-氨基头孢烷酸。

    2-amido-7-amino cephalosporanic acids and related compounds
    9.
    发明授权
    2-amido-7-amino cephalosporanic acids and related compounds 失效
    2-AMIDO-7-AMINO CEPHALOSPORANIC酸及相关化合物

    公开(公告)号：US3873533A

    公开(公告)日：1975-03-25

    申请号：US10753771

    申请日：1971-01-18

    Applicant: AMERICAN HOME PROD

    Inventor： BOGASH RICHARD ,  WOLF MILTON ,  SELLSTEDT JOHN H

    IPC: C07D499/00 ,  C07D499/42 ,  C07D99/16 ,  C07D99/24

    CPC classification number: C07D499/00

    Abstract: This invention concerns 2-amido-6-aminopenicillanic acids, 2amido-6-haloimidopenicillins, 2-amido-6-alkoxyimidopenicillins, 2-amido-7-aminocephalosporanic acids, 2-amido-7haloimidocephalosporins and 2-amido-7-alkoxyimidocephalosporins which are useful as intermediates in the preparation of synthetic penicillins and cephalosporins having potent antibiotic activity. Further, it relates to a process for the preparation of these intermediates from penicillins and cephalosporins. Still further, it concerns the preparation of 6-aminopenicillanic acid and 7aminocephalosporanic acid by the respective hydrolysis of 2amido-6-aminopenicillanic acids and 2-amido-7aminocephalosporanic acids.

    Abstract translation: 本发明涉及2-氨基-6-氨基青霉烷酸，2-氨基-6-卤代亚氨基青霉素，2-氨基-6-烷氧基亚氨基青霉素，2-酰胺基-7-氨基头孢烷酸，2-氨基-7-卤代亚氨基头孢菌素和2-氨基-7 - 烷氧基酰氨基头孢菌素，其可用作制备具有有效抗生素活性的合成青霉素和头孢菌素的中间体。 此外，它涉及从青霉素和头孢菌素制备这些中间体的方法。 此外，它涉及通过2-氨基-6-氨基青霉烷酸和2-酰氨基-7-氨基头孢烷酸的相应水解制备6-氨基青霉烷酸和7-氨基头孢烷酸。

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