公开(公告)号：US3635982A

公开(公告)日：1972-01-18

申请号：US3635982D

申请日：1969-04-08

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  C07D51/70

CPC classification number: C07D207/08 ,  C07D207/06 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  Y10S514/826

Abstract: NOVEL AMINO-SUBSTITUTED 2-QUINOXALINYLOXAZOLIDINE - 3AMIDES AND -SULFONAMIDES AND 2-QUINOXALINYOLAZINE-3-AMIDES AND -SULFONAMIDES (1) ARE PROVIDED, WITH PHARMACOLOGICAL ACTIVITY AS CENTRAL NERVOUS SYSTEM DEPRESSANTS AND ULILITY TO INDUCE CALMING. COMPOUNDS (1) ARE PREPARED BY REACTING A 3-(O- OR P-FLUORO-PHENYLSULFONYL- OR -BENZOYL)2-(2-QUINOXALINYL)-OXAZOLIDINE OR OXAZINE (II) WITH A NUCEOPHILIC AGENT, E.G., A ORGANIC AMINE.

公开(公告)号：US3632581A

公开(公告)日：1972-01-04

申请号：US3632581D

申请日：1968-10-08

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D241/42 ,  C07D51/78

CPC classification number: C07D241/42

Abstract: THIS INVENTION CONCERNS SCHIFF BASES OF QUINOXALINE-2CARBOXALDEHYDES AND THE REDUCTION PRODUCTS THEREOF WHICH ARE PHARMACOLOGICALLY ACTIVE AS CENTRAL NERVOUS SYSTEM DEPRESSANTS.

公开(公告)号：US3917680A

公开(公告)日：1975-11-04

申请号：US42931673

申请日：1973-12-28

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07C45/30 ,  C07C45/64 ,  C07C45/67 ,  C07C45/68 ,  C07C49/755 ,  C07C91/02

CPC classification number: C07C317/00 ,  C07C45/30 ,  C07C45/64 ,  C07C45/673 ,  C07C45/68 ,  C07C49/755

Abstract: 5,6,7,8,9,10-Hexahydro-5-phenyl-5,9-methanobenzocyclooctene-11amines, intermediates therefore and processes for their preparation are disclosed. The final products have analgesic activity.

Abstract translation: 5,6,7,8,9,10-六氢-5-苯基-5,9-甲基苯并环辛烯-11-胺，因此其中间体及其制备方法被公开。 最终产品具有止痛活性。

公开(公告)号：US3869512A

公开(公告)日：1975-03-04

申请号：US33381473

申请日：1973-02-20

Applicant: AMERICAN HOME PROD

Inventor： FREED ELISABETH H ,  FREED MEIER E ,  POTOSKI JOHN R

IPC: C07C49/755 ,  C07C91/42 ,  C07C49/76 ,  C07C93/14 ,  C07C119/14 ,  C07C131/00

CPC classification number: C07C49/755

Abstract: Dibenzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates for their preparation, and process for their use. The compounds of the invention exert analgesic activity.

Abstract translation: 二苄基双环链烷胺，其药理学上可接受的加成盐，其制备中间体及其用途。 本发明化合物发挥止痛活性。

公开(公告)号：US3692791A

公开(公告)日：1972-09-19

申请号：US3692791D

申请日：1970-05-18

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D455/02 ,  C07D39/12

CPC classification number: C07D455/02

Abstract: The disclosure is directed to 2-t-butyl-octahydro-2H quinolizines substituted in the two position and having the following formula:

Abstract translation: 本公开涉及在两个位置上取代的具有下式的2-叔丁基 - 八氢-2H-喹嗪：

公开(公告)号：US3647790A

公开(公告)日：1972-03-07

申请号：US3647790D

申请日：1969-04-08

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  C07D87/06

CPC classification number: C07D207/08 ,  C07D207/06 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  Y10S514/826

Abstract: NOVEL 2-QUINOXALINYL-OXAZOLIDINE-3-AMIDES AND -SULFONAMIDES AND 2-QUINOXALINYL-OXAZINE-3-AMIDES AND -SULFONAMIDES (I) ARE PROVIDED, WITH PHARMACOLOGICAL ACTIVITY AS NERVOUS SYSTEM DEPRESSANTS AND UTILITY TO INDUCE CALMING. COMPOUNDS (I) ARE PREPARED BY CONDENSING A ((2-QUINOXALINYLMETHYLENE)AMINE)ALKANOL (II) WITH A BENZYOL- OR PHENYLSULFONYL-CHLORIDE (III).