公开(公告)号：US20180105589A1

公开(公告)日：2018-04-19

申请号：US15696138

申请日：2017-09-05

Applicant: AMGEN INC.

Inventor： Thomas M. DILLON ,  Pavel BONDARENKO ,  Jette WYPYCH ,  Martin J. ALLEN ,  Alain BALLAND ,  Margaret Speed RICCI ,  Amy GUO ,  Wenyan SHEN ,  Jeonghoon SUN ,  Christopher J. VEZINA

IPC: C07K16/24 ,  C07K16/28 ,  C07K16/00

CPC classification number: C07K16/245 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2875 ,  C07K2317/53 ,  C07K2317/56

Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.