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公开(公告)号：US09636418B2
公开(公告)日：2017-05-02
申请号：US14207445
申请日：2014-03-12
申请人： AMGEN INC.
发明人： Justin K. Murray , Jerry Ryan Holder , Malgorzata Wanska , Christopher M. Tegley , James R. Falsey , Elizabeth M. Doherty , Leslie P. Miranda
IPC分类号： C07K14/435 , A61K47/48 , C07K16/44 , C07K14/705 , A61K38/00
CPC分类号： A61K47/48438 , A61K38/00 , A61K47/60 , A61K47/68 , A61K47/6817 , C07K14/43518 , C07K14/705 , C07K16/44
摘要： Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted NaV1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of NaV1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.
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公开(公告)号：US11766436B2
公开(公告)日：2023-09-26
申请号：US17363878
申请日：2021-06-30
申请人： Amgen Inc.
发明人： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC分类号： A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC分类号： A61K31/517 , A61K31/4985 , A61K39/39558 , A61P35/00 , C07D403/04 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US10532042B2
公开(公告)日：2020-01-14
申请号：US15849905
申请日：2017-12-21
申请人： AMGEN INC.
发明人： Brian Alan Lanman , Victor J. Cee , Alexander J. Pickrell , Anthony B. Reed , Kevin C. Yang , David John Kopecky , Hui-Ling Wang , Patricia Lopez , Kate Ashton , Shon Booker , Christopher M. Tegley
IPC分类号： C07D487/04 , A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D401/04 , C07D403/04 , C07D239/80 , C07D417/04 , C07D471/04 , C07D471/08 , C07D487/10 , C07D275/04 , C07D513/04
摘要： Provided herein are KRAS G12C inhibitors, compounds of formula (II), or a pharmaceutically acceptable salt thereof: compositions of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US10344060B2
公开(公告)日：2019-07-09
申请号：US14773756
申请日：2014-03-12
申请人： AMGEN INC.
发明人： Justin K. Murray , Jerry Ryan Holder , Malgorzata Wanska , Christopher M. Tegley , James R. Falsey , Elizabeth M. Doherty , Leslie P. Miranda , Kaustav Biswas , Bin Wu , Kelvin Sham , Jason C. Long
IPC分类号： C07K14/00 , C07K14/435 , C07K16/00 , C07K19/00 , C07K14/46 , C07K14/47 , A61K38/00 , A61K38/16 , A61K38/17 , A61K47/64 , A61K47/68
摘要： Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted NaV1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of NaV1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.
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公开(公告)号：US11285135B2
公开(公告)日：2022-03-29
申请号：US16675121
申请日：2019-11-05
申请人： AMGEN INC.
发明人： Brian Alan Lanman , Victor J. Cee , Alexander J. Pickrell , Anthony B. Reed , Kevin C. Yang , David John Kopecky , Hui-Ling Wang , Patricia Lopez , Kate Ashton , Shon Booker , Christopher M. Tegley
IPC分类号： C07D417/04 , C07D417/14 , C07D513/04 , A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D487/04 , C07D239/80 , C07D487/10 , C07D471/04
摘要： Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11090304B2
公开(公告)日：2021-08-17
申请号：US16402538
申请日：2019-05-03
申请人： Amgen Inc.
发明人： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC分类号： A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11053226B2
公开(公告)日：2021-07-06
申请号：US16687546
申请日：2019-11-18
申请人： Amgen Inc.
发明人： Youngsook Shin , Victor J. Cee , Christopher M. Tegley , Brian Alan Lanman , Ryan Paul Wurz , Kevin C. Yang , Vu Van Ma , Daniel Erlanson , Joon Won Jeong , Raymond V. Fucini , Jeffrey Iwig
IPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61P35/00
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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