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公开(公告)号：US10465009B2
公开(公告)日：2019-11-05
申请号：US14649469
申请日：2013-12-05
申请人： Amgen Inc.
发明人： Richard J. Armitage , Michelle Blake , William C. Fanslow, III , Jason Charles O'Neill , Gunasekaran Kannan , Jiangchun Xu , Mark Edward Tometsko , Zhulun Wang , Athena Sudom
摘要： The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.
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2.发明申请公开(公告)号：US20190085054A1
公开(公告)日：2019-03-21
申请号：US16209239
申请日：2018-12-04
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US10220090B2
公开(公告)日：2019-03-05
申请号：US14967167
申请日：2015-12-11
申请人： Amgen Inc.
发明人： Richard J. Armitage , Michelle Blake , William C. Fanslow, III , Jason Charles O'Neill , Gunasekaran Kannan , Jiangchun Xu , Mark Edward Tometsko
IPC分类号： C07K16/18 , A61K45/06 , A61K39/00 , C07K16/28 , A61K39/395 , A61K31/395 , A61K47/68
摘要： The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.
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4.发明申请VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS 审中-公开金属蛋白酶三类（TIMP-3）组织抑制剂的变体，组成和方法公开(公告)号：US20160031969A1
公开(公告)日：2016-02-04
申请号：US14775482
申请日：2014-03-13
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
IPC分类号： C07K14/81
CPC分类号： C07K14/8146 , A61K38/00 , C12N9/6489
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
摘要翻译： 公开了TIMP-3突变蛋白，变体和衍生物，编码它们的核酸，以及制备和使用它们的方法。
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5.发明授权公开(公告)号：US10189890B2
公开(公告)日：2019-01-29
申请号：US14775482
申请日：2014-03-13
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
IPC分类号： C07K14/435 , A61K38/16 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/63 , C07K14/81 , C12N9/64 , A61K38/00
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US09243058B2
公开(公告)日：2016-01-26
申请号：US14098275
申请日：2013-12-05
申请人： Amgen Inc.
发明人： Richard J. Armitage , Michelle Blake , William C. Fanslow, III , Jason Charles O'Neill , Gunasekaran Kannan , Jiangchun Xu , Mark Edward Tometsko
CPC分类号： A61K39/3955 , A61K31/395 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6867 , A61K2039/505 , A61K2039/572 , C07K16/18 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.
摘要翻译： 本发明涉及BCMA（B细胞成熟抗原）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗疾病的组合物和方法。 本发明还涉及BCMA抗体药物偶联物。
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