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公开(公告)号：US09982054B2
公开(公告)日：2018-05-29
申请号：US15178652
申请日：2016-06-10
申请人： Amgen Inc.
发明人： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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2.发明申请VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS 审中-公开金属蛋白酶三类（TIMP-3）组织抑制剂的变体，组成和方法公开(公告)号：US20160031969A1
公开(公告)日：2016-02-04
申请号：US14775482
申请日：2014-03-13
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
IPC分类号： C07K14/81
CPC分类号： C07K14/8146 , A61K38/00 , C12N9/6489
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
摘要翻译： 公开了TIMP-3突变蛋白，变体和衍生物，编码它们的核酸，以及制备和使用它们的方法。
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公开(公告)号：US20210024626A1
公开(公告)日：2021-01-28
申请号：US17060905
申请日：2020-10-01
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K47/68 , A61K39/395
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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4.发明授权公开(公告)号：US10189890B2
公开(公告)日：2019-01-29
申请号：US14775482
申请日：2014-03-13
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
IPC分类号： C07K14/435 , A61K38/16 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/63 , C07K14/81 , C12N9/64 , A61K38/00
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US11965029B2
公开(公告)日：2024-04-23
申请号：US17339301
申请日：2021-06-04
申请人： Amgen Inc.
发明人： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC分类号： C07K16/2866 , C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要： Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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6.发明授权公开(公告)号：US11149078B2
公开(公告)日：2021-10-19
申请号：US15547730
申请日：2015-08-26
申请人： AMGEN INC.
发明人： Jason C. O'Neill , Randal R. Ketchem , Taeweon Lee , Vishnu Chintalgattu , Jennitte Leann Stevens
摘要： The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.
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公开(公告)号：US20190322737A1
公开(公告)日：2019-10-24
申请号：US16453482
申请日：2019-06-26
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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8.发明申请公开(公告)号：US20190085054A1
公开(公告)日：2019-03-21
申请号：US16209239
申请日：2018-12-04
申请人： AMGEN INC.
发明人： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
摘要： There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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公开(公告)号：US09951129B2
公开(公告)日：2018-04-24
申请号：US15271315
申请日：2016-09-21
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C12N15/24 , C07K16/24 , A61K39/395 , A61K47/68 , A61K39/00
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20170002070A1
公开(公告)日：2017-01-05
申请号：US15271315
申请日：2016-09-21
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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