公开(公告)号：US10736883B2

公开(公告)日：2020-08-11

申请号：US16347903

申请日：2017-11-03

申请人： AMGEN INC.

发明人： Matthew Brown ,  Ning Chen ,  Xiaoqi Chen ,  Yinhong Chen ,  Alan C. Cheng ,  Richard V. Connors ,  Jeffrey Deignan ,  Paul John Dransfield ,  Xiaohui Du ,  Zice Fu ,  James S. Harvey ,  Julie Anne Heath ,  Lars V. Heumann ,  Jonathan Houze ,  Frank Kayser ,  Aarif Yusuf Khakoo ,  David j. Kopecky ,  Su-Jen Lai ,  Zhihua Ma ,  Julio C. Medina ,  Jeffrey T. Mihalic ,  Steven H. Olson ,  Vatee Pattaropong ,  Gayathri Swaminath ,  Xiaodong Wang ,  Malgorzata Wanska ,  Wen-Chen Yeh

IPC分类号： A61K31/4196 ,  A61K31/341 ,  C07D405/04 ,  C07D405/14 ,  A61K31/421 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  C07D239/26 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07F7/08 ,  A61P9/00 ,  A61P9/02 ,  C07D307/54

摘要： Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

公开(公告)号：US11046680B1

公开(公告)日：2021-06-29

申请号：US16347910

申请日：2017-11-03

申请人： AMGEN INC.

发明人： Ning Chen ,  Xiaoqi Chen ,  Yinhong Chen ,  Alan C. Cheng ,  Richard V. Connors ,  Jeffrey Deignan ,  Paul John Dransfield ,  Xiaohui Du ,  Zice Fu ,  James S. Harvey ,  Julie Anne Heath ,  Lars V. Heumann ,  Daniel B. Horne ,  Jonathan Houze ,  Matthew R. Kaller ,  Frank Kayser ,  Aarif Yusuf Khakoo ,  David J. Kopecky ,  Su-Jen Lai ,  Zhihua Ma ,  Julio C. Medina ,  Jeffrey T. Mihalic ,  Nobuko Nishimura ,  Steven H. Olson ,  Vatee Pattaropong ,  Gayathri Swaminath ,  Xiaodong Wang ,  Malgorzata Wanska ,  Kevin Yang ,  Wen-Chen Yeh

IPC分类号： C07D417/14 ,  A61P9/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.