公开(公告)号：US20140308285A1

公开(公告)日：2014-10-16

申请号：US14207368

申请日：2014-03-12

Applicant: Amgen Inc.

Inventor： Wei YAN ,  Martin J. PENTONY ,  Luis G. BORGES ,  Mark L. MICHAELS

IPC: C07K16/46

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/64

Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.

Abstract translation: 本文提供了可以通过免疫效应细胞介导靶细胞的细胞溶解的异二聚体双特异性抗体，编码这种抗体的核酸，制备此类抗体的方法以及使用这种抗体的方法。 这些抗体包含两个不同的多肽链，每条链包含两个免疫球蛋白可变区和任选的半衰期延长部分。

公开(公告)号：US20140024111A1

公开(公告)日：2014-01-23

申请号：US14037040

申请日：2013-09-25

Applicant: AMGEN INC.

Inventor： Gunasekaran KANNAN ,  Michael WITTEKIND ,  Wei YAN ,  Martin J. PENTONY

IPC: C07K16/00

CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K16/468 ,  C07K2317/52 ,  C07K2317/526

Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.

Abstract translation: 本发明涉及制备Fc-异二聚体蛋白或多肽的方法。 本发明还涉及Fc-异二聚体蛋白或多肽本身，包括包含编码这种多肽，表达载体和宿主细胞的异二聚体核酸的单个多肽组分。 此外，本发明涉及包含更多Fc-异二聚体蛋白质或多肽之一的药物组合物。