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    Fc VARIANTS
    3.
    发明申请
    Fc VARIANTS 审中-公开

    公开(公告)号：US20200010545A1

    公开(公告)日：2020-01-09

    申请号：US16413810

    申请日：2019-05-16

    Applicant: AMGEN INC.

    Inventor： Zhi LIU ,  Gunasekaran KANNAN ,  Wei YAN

    IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

    Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.

    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
    4.
    发明申请
    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 审中-公开
    人体抗原结合蛋白质，其结合了转化子分泌素KEXIN 9型

    公开(公告)号：US20160032014A1

    公开(公告)日：2016-02-04

    申请号：US14777401

    申请日：2014-03-14

    Applicant: AMGEN INC.

    Inventor： Mark Leo MICHAELS ,  Randal R. KETCHEM ,  Derek E. PIPER ,  Wei YAN ,  Chadwick Terence KING ,  Monique LaRae HOWARD

    IPC: C07K16/40

    CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inhibiting PCSK9 binding to LDLR and having increased pH sensitivity, improved binding affinity and/or increased in vivos half life. In embodiments, the antigen binding proteins specifically bind PCSK9 and have increased pH sensitivity, improved binding affinity and/or increased in vivos half life. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind PCSK9 Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from hypercholesterolemia and related disorders or conditions.

    Abstract translation: 本发明提供与能够抑制PCSK9与LDLR结合并具有增加的pH敏感性，改善的结合亲和力和/或增加活体半衰期的抗原结合蛋白质有关或衍生的组合物和方法。 在实施方案中，抗原结合蛋白特异性结合PCSK9并具有增加的pH敏感性，改善的结合亲和力和/或增加活体半衰期。 在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，此类抗体的结合片段和衍生物，以及特异性结合PCSK9的多肽其他实施方案提供编码此类抗原结合蛋白的核酸及其片段和衍生物， 和多肽，包含此类多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物，以及多肽，以及使用此类抗原结合蛋白，其片段及其衍生物和多肽的方法，包括治疗或诊断受试者的方法 来自高胆固醇血症和相关疾病或病症。

    HETERODIMERIC BISPECIFIC ANTIBODIES
    5.
    发明申请
    HETERODIMERIC BISPECIFIC ANTIBODIES 审中-公开
    双相异种抗体

    公开(公告)号：US20140308285A1

    公开(公告)日：2014-10-16

    申请号：US14207368

    申请日：2014-03-12

    Applicant: Amgen Inc.

    Inventor： Wei YAN ,  Martin J. PENTONY ,  Luis G. BORGES ,  Mark L. MICHAELS

    IPC: C07K16/46

    CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/64

    Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.

    Abstract translation: 本文提供了可以通过免疫效应细胞介导靶细胞的细胞溶解的异二聚体双特异性抗体，编码这种抗体的核酸，制备此类抗体的方法以及使用这种抗体的方法。 这些抗体包含两个不同的多肽链，每条链包含两个免疫球蛋白可变区和任选的半衰期延长部分。

    BISPECIFIC-Fc MOLECULES
    6.
    发明申请
    BISPECIFIC-Fc MOLECULES 审中-公开
    BISPECIFIC-Fc分子

    公开(公告)号：US20140302037A1

    公开(公告)日：2014-10-09

    申请号：US14210178

    申请日：2014-03-13

    Applicant: Amgen Inc.

    Inventor： Luis G. BORGES ,  Patrick A. BAEUERLE ,  Wei YAN ,  Mark L. MICHAELS

    IPC: C07K16/46

    Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

    Abstract translation: 本文描述的是含有Fc多肽链和免疫球蛋白可变区的双特异性分子。 还提供了包含这种分子的药物制剂，编码这种分子的核酸，含有这种核酸的宿主细胞，制备这种分子的方法，以及使用这种分子的方法。

    HOST CELL FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS
    7.
    发明申请
    HOST CELL FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS 审中-公开
    使用静电转向效应制备抗体FC-HETERLDERIC分子的主体细胞

    公开(公告)号：US20140024111A1

    公开(公告)日：2014-01-23

    申请号：US14037040

    申请日：2013-09-25

    Applicant: AMGEN INC.

    Inventor： Gunasekaran KANNAN ,  Michael WITTEKIND ,  Wei YAN ,  Martin J. PENTONY

    IPC: C07K16/00

    CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K16/468 ,  C07K2317/52 ,  C07K2317/526

    Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.

    Abstract translation: 本发明涉及制备Fc-异二聚体蛋白或多肽的方法。 本发明还涉及Fc-异二聚体蛋白或多肽本身，包括包含编码这种多肽，表达载体和宿主细胞的异二聚体核酸的单个多肽组分。 此外，本发明涉及包含更多Fc-异二聚体蛋白质或多肽之一的药物组合物。

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