公开(公告)号：US20140024111A1

公开(公告)日：2014-01-23

申请号：US14037040

申请日：2013-09-25

Applicant: AMGEN INC.

Inventor： Gunasekaran KANNAN ,  Michael WITTEKIND ,  Wei YAN ,  Martin J. PENTONY

IPC: C07K16/00

CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K16/468 ,  C07K2317/52 ,  C07K2317/526

Abstract: The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.

Abstract translation: 本发明涉及制备Fc-异二聚体蛋白或多肽的方法。 本发明还涉及Fc-异二聚体蛋白或多肽本身，包括包含编码这种多肽，表达载体和宿主细胞的异二聚体核酸的单个多肽组分。 此外，本发明涉及包含更多Fc-异二聚体蛋白质或多肽之一的药物组合物。