公开(公告)号：US12208238B2

公开(公告)日：2025-01-28

申请号：US17360140

申请日：2021-06-28

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M5/145 ,  A61M5/158 ,  A61M5/32 ,  A61M39/14

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

公开(公告)号：US20220096747A1

公开(公告)日：2022-03-31

申请号：US17426194

申请日：2020-02-11

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Paul Daniel Faucher ,  Antonio S. Murcia ,  Nathan Thomas Balcom ,  William Wistar Rhoads ,  Nicholas D.M. Prsha

IPC: A61M5/168 ,  A61M5/36 ,  A61M5/145 ,  A61M39/22

Abstract: A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material that exerts an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container or the supply line and includes a digital controller, a fluid valve operably coupled to the digital controller, and a diaphragm assembly in fluid communication with the fluid valve and operably coupled to the digital controller. The fluid valve, the diaphragm assembly, and the digital controller cooperate to regulate a flow rate of the drug.

公开(公告)号：US11083840B2

公开(公告)日：2021-08-10

申请号：US15995442

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M39/14 ,  A61M5/145 ,  A61M5/32 ,  A61M5/158

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.