公开(公告)号：US12208238B2

公开(公告)日：2025-01-28

申请号：US17360140

申请日：2021-06-28

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M5/145 ,  A61M5/158 ,  A61M5/32 ,  A61M39/14

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

公开(公告)号：US11890450B2

公开(公告)日：2024-02-06

申请号：US16297408

申请日：2019-03-08

Applicant: AMGEN INC.

Inventor： Lawrence Scott Ring ,  Tohid Pirbodaghi ,  Samin Akbari ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Mark Gordon ,  Mikhail Tikh ,  Jimmie L. Ward ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul Faucher ,  Jeff Lind

IPC: A61M5/168 ,  A61M5/14 ,  A61M5/142 ,  A61M5/158 ,  A61M39/24 ,  A61M5/145 ,  A61M5/155

CPC classification number: A61M5/16813 ,  A61M5/1413 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/16822 ,  A61M39/24 ,  A61M5/14526 ,  A61M5/155 ,  A61M2005/1403 ,  A61M2005/1406 ,  A61M2005/14252 ,  A61M2039/244 ,  A61M2039/2406 ,  A61M2039/248 ,  A61M2039/2426 ,  A61M2205/3561 ,  A61M2205/505 ,  A61M2205/7527 ,  A61M2205/7536 ,  A61M2209/045

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

公开(公告)号：US11744950B2

公开(公告)日：2023-09-05

申请号：US16969691

申请日：2019-02-12

Applicant: AMGEN INC.

Inventor： Joel Perez-Pacheco ,  Lawrence Scott Ring

IPC: A61M5/315 ,  A61M5/31

CPC classification number: A61M5/31501 ,  A61M5/3129

Abstract: A syringe is described with a plunger assembly that is adapted to have a dispensing stroke sized to dispense a fluid therapeutic product from the syringe without dispensing any air or headspace. The syringe includes a plunger rod having a stop feature that stops a dispensing stroke of the plunger rod at a distance corresponding to a level of air or headspace within the syringe avoiding additional air dispensing steps from a healthcare provider.

公开(公告)号：US11083840B2

公开(公告)日：2021-08-10

申请号：US15995442

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Scott Robert Gibson ,  Sudeshna Dutta Ray ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Nathan Thomas Balcom ,  Alejandro Campillo-Agusti ,  Alan D. Payne ,  Lawrence Scott Ring

IPC: A61M5/162 ,  A61M39/14 ,  A61M5/145 ,  A61M5/32 ,  A61M5/158

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

公开(公告)号：US20210001052A1

公开(公告)日：2021-01-07

申请号：US16969691

申请日：2019-02-12

Applicant: AMGEN INC.

Inventor： Joel Perez-Pacheco ,  Lawrence Scott Ring

IPC: A61M5/315 ,  A61M5/31

Abstract: A syringe is described with a plunger assembly that is adapted to have a dispensing stroke sized to dispense a fluid therapeutic product from the syringe without dispensing any air or headspace. The syringe includes a plunger rod having a stop feature that stops a dispensing stroke of the plunger rod at a distance corresponding to a level of air or headspace within the syringe avoiding additional air dispensing steps from a healthcare provider.