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公开(公告)号：US12012449B2
公开(公告)日：2024-06-18
申请号：US17525421
申请日：2021-11-12
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： A61K39/395 , A61K47/68 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20210230267A1
公开(公告)日：2021-07-29
申请号：US17229607
申请日：2021-04-13
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K47/68 , A61K39/395
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20210024626A1
公开(公告)日：2021-01-28
申请号：US17060905
申请日：2020-10-01
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K47/68 , A61K39/395
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20160159914A1
公开(公告)日：2016-06-09
申请号：US14886565
申请日：2015-10-19
申请人： AMGEN INC.
发明人： Alison L. Budelsky , Jennifer E. Towne , Yu Zhang , Lori Siegel , Antony Symons
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagonists of the IL-17RA-IL-17RE heteromeric receptor complex are disclosed, as well as various methods of use.
摘要翻译： 本发明涉及白细胞介素-17配体和受体家族成员以及IL-17受体A和IL-17受体E形成具有生物活性的异聚受体复合物的发现，并且IL-17C活性需要IL-17RA- IL-17RE异聚受体复合物。 公开了IL-17RA-IL-17RE异聚受体复合物的拮抗剂以及各种使用方法。
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公开(公告)号：US20220056122A1
公开(公告)日：2022-02-24
申请号：US17525421
申请日：2021-11-12
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randel R. Ketchem
IPC分类号： C07K16/24 , A61K47/68 , A61K39/395
摘要： Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.
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公开(公告)号：US20190322737A1
公开(公告)日：2019-10-24
申请号：US16453482
申请日：2019-06-26
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US09951129B2
公开(公告)日：2018-04-24
申请号：US15271315
申请日：2016-09-21
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C12N15/24 , C07K16/24 , A61K39/395 , A61K47/68 , A61K39/00
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20170002070A1
公开(公告)日：2017-01-05
申请号：US15271315
申请日：2016-09-21
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号：US20200181255A1
公开(公告)日：2020-06-11
申请号：US16793610
申请日：2020-02-18
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20190071498A1
公开(公告)日：2019-03-07
申请号：US16194896
申请日：2018-11-19
申请人： AMGEN INC.
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K39/395 , A61K47/68 , A61K39/00
摘要： Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.
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