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公开(公告)号：US20220362104A1
公开(公告)日：2022-11-17
申请号：US17770355
申请日：2020-10-23
发明人： Cornelius Pompe , Nicholas J. Clark , Wei Qi , Arnold J. McAuley , MIchael Schneider , Chia-Jung Wu , Twinkle R. Christian , Heather N. Franey , Bharadwaj Jagannathan , Jeffrey Abel , Franz Dietzel
摘要： An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.
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公开(公告)号：US11419933B2
公开(公告)日：2022-08-23
申请号：US15414723
申请日：2017-01-25
IPC分类号： A61K39/395 , C07K16/28 , A61K9/00 , A61K47/18 , A61K9/16 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/40 , B01D61/14 , A61K39/00
摘要： The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
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公开(公告)号：US20200048357A1
公开(公告)日：2020-02-13
申请号：US16373083
申请日：2019-04-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/28 , A61K39/395 , C12N5/16 , C12N15/63
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US10301391B2
公开(公告)日：2019-05-28
申请号：US15422619
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11352433B2
公开(公告)日：2022-06-07
申请号：US16373083
申请日：2019-04-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/28 , C12N5/10 , C12N5/12 , C12N15/63 , A61K39/395 , C12N5/16 , C07K14/715 , A61K39/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170218077A1
公开(公告)日：2017-08-03
申请号：US15422619
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/94 , C07K2319/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20200332000A1
公开(公告)日：2020-10-22
申请号：US16482603
申请日：2018-02-02
发明人： Arnold Mcauley , Pavan Ghattyvenkatakrishna , Jeff Abel , Joon Huh , Cornelius Pompe , Sekhar Kanapuram , Michael Treuheit , Bharadwaj Jagannathan
摘要： The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.
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公开(公告)号：US20170209571A1
公开(公告)日：2017-07-27
申请号：US15414723
申请日：2017-01-25
IPC分类号： A61K39/395 , A61K47/40 , A61K47/10 , B01D61/14 , A61K47/02 , A61K47/26 , A61K9/19 , A61K9/16 , C07K16/28 , A61K47/12
CPC分类号： A61K39/3955 , A61K9/0019 , A61K9/1652 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/40 , A61K2039/505 , B01D61/145 , B01D2315/16 , C07K16/2803 , C07K16/2809 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94
摘要： The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
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公开(公告)号：US10781264B2
公开(公告)日：2020-09-22
申请号：US15422661
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20230192884A1
公开(公告)日：2023-06-22
申请号：US17812061
申请日：2022-07-12
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , C07K16/46
CPC分类号： C07K16/30 , C07K16/2863 , C07K16/2803 , C07K16/3053 , C07K16/2875 , C07K16/2887 , A61K39/39558 , C07K16/28 , C07K16/2809 , C07K16/468 , C07K2317/33 , C07K2319/00 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/94
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3cε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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