公开(公告)号：US10000456B2

公开(公告)日：2018-06-19

申请号：US14283322

申请日：2014-05-21

Applicant: AMIRA PHARMACEUTICALS, INC.

Inventor： Ryan Clark ,  Brian Andrew Stearns ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie M. Arruda

IPC: C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D231/38 ,  C07D261/08 ,  C07D261/14 ,  C07D417/12 ,  C07D413/14

CPC classification number: C07D231/38 ,  C07D261/08 ,  C07D261/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

公开(公告)号：US09624182B2

公开(公告)日：2017-04-18

申请号：US14755383

申请日：2015-06-30

Applicant: Amira Pharmaceuticals, Inc.

Inventor： Thomas J. Seiders ,  Lucy Zhao ,  Jeannie Arruda ,  Bowei Wang ,  Brian Andrew Stearns ,  Yen Pham Truong ,  Jill Melissa Scott ,  John Howard Hutchinson ,  Ryan Clark ,  Heather Renee Coate ,  Nicholas Simon Stock ,  Deborah Volkots

IPC: C07D417/12 ,  C07D413/06 ,  C07D413/12 ,  C07D495/04 ,  C07D261/08 ,  C07D261/14 ,  A61K31/519 ,  A61K31/4725 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/4709 ,  C07D261/18 ,  C07D405/12 ,  A61K31/42 ,  A61K31/422

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  C07D261/14 ,  C07D261/18 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

公开(公告)号：US20150329502A1

公开(公告)日：2015-11-19

申请号：US14755383

申请日：2015-06-30

Applicant: Amira Pharmaceuticals, Inc.

Inventor： Thomas J. Seiders ,  Lucy Zhao ,  Jeannie Arruda ,  Bowei Wang ,  Brian Andrew Stearns ,  Yen Pham Truong ,  Jill Melissa Scott ,  John Howard Hutchinson ,  Ryan Clark ,  Heather Renee Coate ,  Nicholas Simon Stock ,  Deborah Volkots

IPC: C07D261/14 ,  C07D261/18 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D261/08 ,  C07D413/06

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  C07D261/14 ,  C07D261/18 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract translation: 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。

公开(公告)号：US09849109B2

公开(公告)日：2017-12-26

申请号：US14628970

申请日：2015-02-23

Applicant: Amira Pharmaceuticals, Inc.

Inventor： Jeffrey Roger Roppe ,  Timothy Andrew Parr ,  Nicholas Simon Stock ,  Deborah Volkots ,  John Howard Hutchinson

IPC: C07D209/36 ,  C07D209/30 ,  A61K31/404 ,  C07D209/08 ,  C07D209/12 ,  C07D209/32 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D409/04 ,  C07D417/04 ,  C07D401/10 ,  C07D403/12 ,  C07F5/02 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/69

CPC classification number: A61K31/404 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/69 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/32 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D417/04 ,  C07F5/025

Abstract: Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.

公开(公告)号：US20150164861A1

公开(公告)日：2015-06-18

申请号：US14628970

申请日：2015-02-23

Applicant: Amira Pharmaceuticals, Inc.

Inventor： Jeffrey Roger Roppe ,  Timothy Andrew Parr ,  Nicholas Simon Stock ,  Deborah Volkots ,  John Howard Hutchinson

IPC: A61K31/404 ,  A61K31/506 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/501 ,  A61K31/41 ,  A61K31/69 ,  A61K31/4439 ,  A61K31/427

CPC classification number: A61K31/404 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/69 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/32 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D417/04 ,  C07F5/025

Abstract: Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.

Abstract translation: 本文描述的是作为自分泌素的抑制剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及将这些抑制剂单独使用并与其它化合物组合用于治疗自体素受体依赖性或自体贴剂介导的病症或疾病的方法。

公开(公告)号：US20140256744A1

公开(公告)日：2014-09-11

申请号：US14283322

申请日：2014-05-21

Applicant: AMIRA PHARMACEUTICALS, INC.

Inventor： Ryan Clark ,  Brian Andrew Stearns ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie M. Arruda

IPC: C07D417/12 ,  C07D413/06 ,  C07D413/12 ,  C07D231/38

CPC classification number: C07D231/38 ,  C07D261/08 ,  C07D261/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract translation: 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。