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公开(公告)号：US20220002651A1
公开(公告)日：2022-01-06
申请号：US17293993
申请日：2019-11-14
发明人： Seon Ho JANG , Hee Sung PARK , Kyung Gu HAN , Dong Sik SEO , Song Hee KOO , Ji Young KIM , Hyo Jung LEE , Su Yeon LEE , In Yong SEO , Seoung Hoon LEE , Chan KIM
IPC分类号： C12M1/12
摘要： Provided is a cell culture sheet for a large-capacity incubator. A cell culture sheet according to one embodiment of the present invention is a cell culture sheet provided in a large-capacity incubator having a plurality of sheets disposed to be spaced apart at predetermined intervals therein, wherein the cell culture sheet has an area of 100 cm2 or more and a bending depth of 0.5 cm or less. As such, even when the culture sheets are closely placed in a limited volume of space, there is little sagging or shape deformation in a specific direction to prevent the occurrence of contact with adjacent culture sheets, thereby preventing a decrease in cell culture volume due to a dead space. Furthermore, since the flow of a cell culture fluid due to the occurrence of contact can be minimized or prevented, a large capacity of cells can be stably and smoothly cultivated such that the cell culture sheet is very suitable for a large-capacity incubator and can be widely applied to the cell culture industry.
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公开(公告)号：US20230080853A1
公开(公告)日：2023-03-16
申请号：US17904339
申请日：2021-02-17
发明人： SeonHo JANG , Hee Sung PARK , Sung Il KIM , Seam MUN , Song Hee KOO , Su Yeon LEE , Ji Young KIM , In Yong SEO , Seoung Hoon LEE , Chan KIM
摘要： A method for manufacturing a fiber assembly for providing a binding surface to a bio-substance is provided. A fiber assembly for providing a binding surface to a bio-substance according to an embodiment of the present invention is manufactured by a method comprising the steps of: (1) preparing a fiber assembly in which a plurality of fibers is accumulated; and (2) performing modification to provide the fiber surface with a carboxyl group reactive to an amine group present in a bio-substance. According to the method, a bio-substance can be easily introduced at a high content into the fiber assembly. In addition, bio-substances that are conjugated therebetween and adsorbed through physical adsorption, etc. are remarkably reduced in the introduction procedure of bio-substances, whereby bio-substances can be availed with high precision and reliability in applications employing bio-substances. Furthermore, applications employing bio-substances can undergo minimal property variations attributed to the bio-substances as detachment of the bio-substances is minimized or prevented. Accordingly, the bio-substances fixed on the surface of the fiber assembly according to the present invention can find a broad spectrum of applications in various fields including the material engineering, bio engineering, medical fields, and so on.
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公开(公告)号：US20220389362A1
公开(公告)日：2022-12-08
申请号：US17754995
申请日：2020-10-12
发明人： Hee Sung PARK , In Yong SEO , Seoung Hoon LEE , Seon Ho JANG , Su Yeon LEE , Ji Young KIM , Hyo Jung LEE
摘要： A cell culture apparatus is provided. A cell culture apparatus according to one exemplary embodiment of the present invention comprises: a cell culture part comprising an accommodation space in which a plurality of supports for cell culture are disposed; a medium supply part for storing a predetermined amount of medium to be supplied to the cell culture part, and maintaining a predetermined carbon dioxide concentration of the medium stored therein by using carbon dioxide introduced from the outside through a gas supply port; and a pump, which interconnects the cell culture part and the medium supply part so as to circulate, in the cell culture part, a medium stored in the medium supply part.
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公开(公告)号：US20220389360A1
公开(公告)日：2022-12-08
申请号：US17754994
申请日：2020-10-12
发明人： Hee Sung PARK , In Yong SEO , Seoung Hoon LEE , Kyung Gu HAN , Seon Ho JANG , Jae Yun KIM , Su Yeon LEE , Ji Young KIM , Hyo Jung LEE
摘要： A cell culture device is provided. A cell culture device according to an exemplary embodiment of the present invention comprises: a housing which has a plurality of through-holes formed through at least one surface thereof to allow carbon dioxide to be introduced thereinto from the outside and includes an inner space filled with a medium for culturing cells; a plurality of supporters which are arranged in the inner space in multiple steps while being spaced at an interval from each other so as to culture cells and are provided in a plate-shape having a predetermined area; and a porous member which is attached to one surface of the housing so as to cover the plurality of through-holes, prevents the medium filled in the inner space from leaking to the outside, and allows carbon dioxide to be introduced into the inner space from the outside.
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公开(公告)号：US20220002654A1
公开(公告)日：2022-01-06
申请号：US17293741
申请日：2019-11-14
发明人： Seon Ho JANG , Kyung Gu HAN , In Yong SEO , Dong Sik SEO , Hee Sung PARK
摘要： A large-scale cell culture system is provided. The large-scale cell culture system according to one embodiment of the present invention includes: an incubator that includes an inner space to provides a culture environment in which a cell is stably cultured; a cell culture part that is disposed in the inner space and includes multiple supporters for cell culture disposed therein; a medium supply part that is disposed in the inner space and stores a predetermined amount of medium supplied to the cell culture part; and a pump that is disposed in the inner space, and is connected to the cell culture part and the medium supply part through a connection pipe, respectively, and circulates the medium so that the medium stored in the medium supply part is recovered to the medium supply part after being supplied to the cell culture part, the multiple supporters being provided in a plate shape having a predetermined area, and arranged in a state separated apart from each other at a predetermined distance along a height direction inside the cell culture part.
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