公开(公告)号：US10816541B2

公开(公告)日：2020-10-27

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok Lee ,  Heung Soo Baek ,  Yung Hyup Joo ,  Jeong Hwan Kim ,  Hong-Ju Shin ,  Mi Young Park ,  Song Seok Shin

IPC: G01N33/50

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US10723693B2

公开(公告)日：2020-07-28

申请号：US15736406

申请日：2016-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Yong Jin Kim ,  Hong-Ju Shin ,  John Hwan Lee

IPC: C07C231/02 ,  C07C213/02 ,  C07C249/08

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

公开(公告)号：US10696611B2

公开(公告)日：2020-06-30

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Song Seok Shin ,  Byoung Young Woo ,  Heung Soo Baek ,  Yong Deog Hong ,  Hong-Ju Shin ,  Yeon Su Jeong ,  Jon Hwan Lee

IPC: C07C239/00 ,  C07D453/02 ,  C07D413/00 ,  A61K31/16 ,  C07C13/615 ,  C07C233/59 ,  A61K31/167 ,  A61K8/42 ,  C07C233/60 ,  A61K8/49 ,  A61Q7/00 ,  A61K31/166 ,  C07C233/63 ,  C07C231/02 ,  C07C233/58 ,  C07C265/12 ,  A61Q19/00 ,  C07D263/56 ,  C07C15/04 ,  C07C233/57 ,  A61K31/4184

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US09433593B1

公开(公告)日：2016-09-06

申请号：US15085628

申请日：2016-03-30

Applicant: Amorepacific Corporation

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Jeong Hwan Kim ,  Chang Geun Yi ,  Hyung Jun Lim ,  Hong-Ju Shin ,  Yongjin Kim ,  Jon Hwan Lee

IPC: A61K31/166 ,  A61K9/20 ,  A61K9/16 ,  A61K9/06 ,  A23L1/30 ,  A61K9/00

CPC classification number: A61K31/166 ,  A23G1/42 ,  A23G3/36 ,  A23G4/12 ,  A23G9/36 ,  A23L33/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1652 ,  A61K9/2059

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-κB and AP-1 or by inhibiting proinflammatory cytokines such as IL-1β.

Abstract translation: 本发明公开的5-金刚烷-1-基-N-（2,4-二羟基苄基）-2,4-二甲氧基苯甲酰胺缺乏毒性，可表现出优异的抗炎作用。 通过抑制一种或多种转录因子NF-κB和AP-1的活性或通过抑制促炎细胞因子，例如通过抑制NO和PGE2中的一种或多种的产生，显示出优异的抗炎作用 IL-1β。

公开(公告)号：US10385011B2

公开(公告)日：2019-08-20

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Soo Jeong Choi ,  Heung Soo Baek ,  Chang Seok Lee ,  Jeong Hwan Kim ,  Yongjin Kim ,  Hong-Ju Shin ,  Ho Sik Rho ,  Song Seok Shin ,  Jon Hwan Lee

IPC: A61K31/16 ,  C07C231/12 ,  C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  A23L29/00 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.