公开(公告)号：US10251862B2

公开(公告)日：2019-04-09

申请号：US15107955

申请日：2015-01-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik Rho ,  Heung Soo Baek ,  Yu Jung Kim ,  Song Seok Shin ,  John Hwan Lee

IPC: A61K31/357 ,  A61K31/36 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.

公开(公告)号：US09433593B1

公开(公告)日：2016-09-06

申请号：US15085628

申请日：2016-03-30

Applicant: Amorepacific Corporation

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Jeong Hwan Kim ,  Chang Geun Yi ,  Hyung Jun Lim ,  Hong-Ju Shin ,  Yongjin Kim ,  Jon Hwan Lee

IPC: A61K31/166 ,  A61K9/20 ,  A61K9/16 ,  A61K9/06 ,  A23L1/30 ,  A61K9/00

CPC classification number: A61K31/166 ,  A23G1/42 ,  A23G3/36 ,  A23G4/12 ,  A23G9/36 ,  A23L33/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1652 ,  A61K9/2059

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-κB and AP-1 or by inhibiting proinflammatory cytokines such as IL-1β.

Abstract translation: 本发明公开的5-金刚烷-1-基-N-（2,4-二羟基苄基）-2,4-二甲氧基苯甲酰胺缺乏毒性，可表现出优异的抗炎作用。 通过抑制一种或多种转录因子NF-κB和AP-1的活性或通过抑制促炎细胞因子，例如通过抑制NO和PGE2中的一种或多种的产生，显示出优异的抗炎作用 IL-1β。

公开(公告)号：US10816541B2

公开(公告)日：2020-10-27

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok Lee ,  Heung Soo Baek ,  Yung Hyup Joo ,  Jeong Hwan Kim ,  Hong-Ju Shin ,  Mi Young Park ,  Song Seok Shin

IPC: G01N33/50

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20150290099A1

公开(公告)日：2015-10-15

申请号：US14648687

申请日：2013-11-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Won Hee Jang ,  Yung Hyup Joo ,  Yang Hui Park ,  Chang Geun Yi ,  Young Suk Cho ,  Heung Soo Baek ,  Song Seok Shin ,  Young Ho Park

IPC: A61K8/42 ,  A61Q19/00

CPC classification number: A61K8/42 ,  A61K8/68 ,  A61K2800/40 ,  A61Q19/007 ,  C07C233/18 ,  C07C235/08 ,  C07C235/28

Abstract: The present invention provides: a novel pseudoceramide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. The present invention has a skin protecting effect in that the invention has a superior effect in skin moisturisation and is outstandingly stable and soluble, and thus the invention can protect the skin from external irritation without side effects, and can be used as an active substance in damaged skin recovery and prevention. Consequently, the invention can be used as a skin-moisturising dermatological external composition, cosmetic composition or pharmaceutical composition.

Abstract translation: 本发明提供：新颖的假花生酰胺化合物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂化物。 本发明具有皮肤保护作用，因为本发明在皮肤保湿中具有优异的效果，并且具有优异的稳定和可溶性，因此本发明可以保护皮肤免受外部刺激而没有副作用，并可用作活性物质 皮肤恢复和预防受损。 因此，本发明可以用作皮肤保湿皮肤病外用组合物，化妆品组合物或药物组合物。

公开(公告)号：US10385011B2

公开(公告)日：2019-08-20

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Soo Jeong Choi ,  Heung Soo Baek ,  Chang Seok Lee ,  Jeong Hwan Kim ,  Yongjin Kim ,  Hong-Ju Shin ,  Ho Sik Rho ,  Song Seok Shin ,  Jon Hwan Lee

IPC: A61K31/16 ,  C07C231/12 ,  C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  A23L29/00 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US10723693B2

公开(公告)日：2020-07-28

申请号：US15736406

申请日：2016-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Yong Jin Kim ,  Hong-Ju Shin ,  John Hwan Lee

IPC: C07C231/02 ,  C07C213/02 ,  C07C249/08

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

公开(公告)号：US10696611B2

公开(公告)日：2020-06-30

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup Joo ,  Song Seok Shin ,  Byoung Young Woo ,  Heung Soo Baek ,  Yong Deog Hong ,  Hong-Ju Shin ,  Yeon Su Jeong ,  Jon Hwan Lee

IPC: C07C239/00 ,  C07D453/02 ,  C07D413/00 ,  A61K31/16 ,  C07C13/615 ,  C07C233/59 ,  A61K31/167 ,  A61K8/42 ,  C07C233/60 ,  A61K8/49 ,  A61Q7/00 ,  A61K31/166 ,  C07C233/63 ,  C07C231/02 ,  C07C233/58 ,  C07C265/12 ,  A61Q19/00 ,  C07D263/56 ,  C07C15/04 ,  C07C233/57 ,  A61K31/4184

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US10525017B2

公开(公告)日：2020-01-07

申请号：US15518428

申请日：2015-10-21

Applicant: Amorepacific Corporation

Inventor： Heung Soo Baek ,  Byeong Yung Woo ,  Se Jin Yoo ,  Yung Hyup Joo ,  Song Seok Shin ,  Mi Hyun Oh ,  John Hwan Lee ,  Seo Young Kim

IPC: A61K31/047 ,  A61K8/34 ,  A61Q19/10 ,  A61K8/30

Abstract: The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.