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公开(公告)号：US20140377798A1
公开(公告)日：2014-12-25
申请号：US14376512
申请日：2013-02-06
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Nicole Staunig , Marta Sut , Bernd Mayer
CPC分类号： C12P19/36 , C12P19/02 , C12P33/00 , C12P41/002
摘要： A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.
摘要翻译： 在一锅反应中用于酶再生氧化还原辅因子NAD + / NADH和NADP + / NADPH的方法，其中作为在相同反应批次（产物形成反应）中进行至少两个进一步的酶催化的氧化还原反应的结果， ，两种氧化还原辅因子之一以其还原形式积聚，分别以其氧化形式累积，其特征在于a）在将还原的辅因子再转化为其原始氧化形式的再生反应中，氧或一般化合物 式R 1 C（O）COOH被还原，b）在将氧化辅因子再转化为其原始还原形式的再生反应中，通式为R 2 CH（OH）R 3的化合物被氧化，其中化合物中的R 1，R 2和R 3具有 不同的意思
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公开(公告)号：US20200239918A1
公开(公告)日：2020-07-30
申请号：US16847861
申请日：2020-04-14
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Bernd Mayer , Alexander Dybov
摘要： The present invention provides a process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars, wherein n is at least 2 and a is at least 1, wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other, wherein, in a first stage, at least one of the sugars which are present at a non-equimolar ratio to each other is oxidized enzymatically and, at the same time, at least one of the other sugars present at a non-equimolar ratio to each other is reduced enzymatically, and wherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted, and which is characterized in that, in at least a second stage, at least a portion of the sugar not converted in the first stage is oxidized enzymatically by half and, respectively, is reduced enzymatically by the remaining half.
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公开(公告)号：US10253340B2
公开(公告)日：2019-04-09
申请号：US14779543
申请日：2014-03-25
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl
IPC分类号： C12P19/02 , C12P19/24 , C07D307/46 , C07D307/58 , A61K38/00
摘要： Disclosed is a method for the isomerization of glucose by reduction to sorbitol and subsequent oxidation to fructose, in which the redox cofactors NAD+/NADH and NADP+/NADPH are regenerated in a one-pot-reaction, wherein one of the two redox cofactors is obtained in the reduced form thereof and the other redox cofactor in the oxidized form thereof as a result of at least two additional enzymatically catalyzed redox reactions (product forming reactions) taking place in the same reaction batch, wherein a) in the regeneration reaction, which transfers the reduced cofactor back to its originally oxidized form, oxygen or a compound of the general formula R1C(O)COOH is reduced, and b) in the regeneration reaction, which transfers the oxidized cofactor back to its originally reduced form, a compound of the general formula R2CH(OH)R3 is oxidized, wherein R1, R2 and R3 have different meanings in the compounds, characterized in that a mixture of glucose and fructose is used as a starting material. Furthermore, the use of fructose thus produced in a method for producing furan derivatives is disclosed.
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公开(公告)号：US10113192B2
公开(公告)日：2018-10-30
申请号：US14763678
申请日：2014-02-05
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Marta Sut , Martina Brandner
IPC分类号： C12P19/02
摘要： A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.
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公开(公告)号：US20160053289A1
公开(公告)日：2016-02-25
申请号：US14779543
申请日：2014-03-25
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl
IPC分类号： C12P19/02 , C07D307/46 , C07D307/58
CPC分类号： C12P19/02 , C07D307/46 , C07D307/58 , C12Y101/01001 , C12Y101/01014 , C12Y101/01307 , C12Y106/01
摘要： Disclosed is a method for the isomerisation of glucose by reduction to sorbitol and subsequent oxidation to fructose, in which the redox cofactors NAD+/NADH and NADP+/NADPH are regenerated in a one-pot-reaction, wherein one of the two redox cofactors is obtained in the reduced form thereof and the other redox cofactor in the oxidised form thereof as a result of at least two additional enzymatically catalysed redox reactions (product forming reactions) taking place in the same reaction batch, wherein a) in the regeneration reaction, which transfers the reduced cofactor back to its originally oxidised form, oxygen or a compound of the general formula R1C(O)COOH is reduced, and b) in the regeneration reaction, which transfers the oxidised cofactor back to its originally reduced form, a compound of the general formula R2CH(OH)R3 is oxidised, wherein R1, R2 and R3 have different meanings in the compounds, characterised in that a mixture of glucose and fructose is used as a starting material. Furthermore, the use of fructose thus produced in a method for producing furan derivatives is disclosed.
摘要翻译： 公开了通过还原成山梨糖醇并随后氧化成果糖来异构化葡萄糖的方法，其中氧化还原辅因子NAD + / NADH和NADP + / NADPH在一锅反应中再生，其中得到两种氧化还原辅因子之一 其还原形式和其氧化形式的其它氧化还原辅因子是由于在相同的反应批次中进行至少两次另外的酶促催化的氧化还原反应（产物形成反应）的结果，其中a）在转移的再生反应中 还原的辅助因子被还原成其原始的氧化形式，氧或通式为R 1 C（O）COOH的化合物被还原，b）在将氧化的辅因子转移回原来还原形式的再生反应中， 通式R2CH（OH）R3被氧化，其中R1，R2和R3在化合物中具有不同的含义，其特征在于将葡萄糖和果糖的混合物用作原料 。 此外，公开了在呋喃衍生物的制造方法中使用果糖。
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公开(公告)号：US20150353978A1
公开(公告)日：2015-12-10
申请号：US14763678
申请日：2014-02-05
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Marta Sut , Martina Brandner
IPC分类号： C12P19/02
CPC分类号： C12P19/02 , C12Y101/01307 , C12Y101/0301
摘要： A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.
摘要翻译： 在一罐合成中从D-葡萄糖酶促生产D-果糖的方法，其中D-葡萄糖酶促氧化成D-葡萄糖并且D-葡糖酮被酶促降解成D-果糖，并且使用D- 以这种方式生产的用于生产呋喃衍生物的果糖。
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公开(公告)号：US20190323051A1
公开(公告)日：2019-10-24
申请号：US16451838
申请日：2019-06-25
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Nicole Staunig , Marta Sut , Bernd Mayer
摘要： A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.
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公开(公告)号：US20170218417A1
公开(公告)日：2017-08-03
申请号：US15490416
申请日：2017-04-18
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Nicole Staunig , Marta Sut , Bernd Mayer
CPC分类号： C12P19/36 , C12P19/02 , C12P33/00 , C12P41/002
摘要： A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.
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公开(公告)号：US09644227B2
公开(公告)日：2017-05-09
申请号：US14376512
申请日：2013-02-06
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Nicole Staunig , Marta Sut , Bernd Mayer
CPC分类号： C12P19/36 , C12P19/02 , C12P33/00 , C12P41/002
摘要： A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.
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公开(公告)号：US11254959B2
公开(公告)日：2022-02-22
申请号：US16304089
申请日：2017-05-18
申请人： ANNIKKI GMBH
发明人： Ortwin Ertl , Bernd Mayer , Nicole Staunig
摘要： The present invention relates to a process for the conversion of D-glucose. The process according to the invention comprises a step a) in which part of the D-glucose is enzymatically oxidized to D-gluconic acid (lactone) and a portion of the D-glucose which is essentially equimolar thereto is reduced to D-sorbitol. In addition to D-glucose, D-fructose is also present in the reaction mixture of step a). The process comprises a further step b) in which D-sorbitol formed from the D-glucose in step a) is enzymatically oxidized to D-fructose.
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