公开(公告)号：US20230323487A1

公开(公告)日：2023-10-12

申请号：US18043012

申请日：2021-08-26

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexander GREEN ,  Zhaoqing YAN ,  Anli TANG

IPC: C12Q1/70 ,  C12Q1/6825 ,  C12N15/115 ,  C12Q1/6818

CPC classification number: C12Q1/701 ,  C12Q1/6825 ,  C12N2310/16 ,  C12Q1/6818 ,  C12N15/115

Abstract: Provided herein are methods and compositions for rapid, highly sensitive detection of SARS-CoV-2, the causative agent of the COVID-19 pandemic or other target nucleic acids. The methods are low-cost and can be implemented in a portable format that does not require elaborate biosafety precautions or sophisticated laboratory equipment.

公开(公告)号：US20190256898A1

公开(公告)日：2019-08-22

申请号：US16342722

申请日：2017-10-17

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander GREEN ,  Duo MA ,  Anli TANG

IPC: C12Q1/6825

Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.