公开(公告)号：US20170297024A1

公开(公告)日：2017-10-19

申请号：US15510126

申请日：2015-09-17

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexandra ROS ,  Bahige G ABDALLAH

IPC: B01L3/00 ,  G01N1/38

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/123 ,  B01L2300/16 ,  B01L2400/0424 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0655 ,  G01N1/38

Abstract: A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.