公开(公告)号：US20190183947A1

公开(公告)日：2019-06-20

申请号：US16304564

申请日：2017-05-25

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Bertram Jacobs ,  Heather Koehler ,  William Arndt ,  Karen Kibler ,  Kelly Trainor ,  Chandra Mitnik ,  Jeffrey Langland

IPC: A61K35/768 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K35/768 ,  A61K9/0019 ,  A61K45/06 ,  A61P35/00 ,  C12N7/00 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132

Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.