公开(公告)号：US20220088178A1

公开(公告)日：2022-03-24

申请号：US17489106

申请日：2021-09-29

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Tsafrir S. Leket-Mor ,  Bertram Jacobs ,  Lydia Meador ,  Karen Kibler

IPC: A61K39/21

Abstract: Disclosed are compositions for generating an immune response against human immunodeficiency virus (HIV) and their methods of uses.

公开(公告)号：US20240226273A1

公开(公告)日：2024-07-11

申请号：US18283042

申请日：2022-03-30

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Bertram Jacobs ,  Karen Kibler

IPC: A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C12N15/86

CPC classification number: A61K39/215 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N2710/24143 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2840/105 ,  C12N2840/206

Abstract: Recombinant poxvirus expressing severe acute respiratory syndrome coronavirus 2 structural proteins and virus-like particles are described, along with methods of making and using the same.

公开(公告)号：US11918642B2

公开(公告)日：2024-03-05

申请号：US17489106

申请日：2021-09-29

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Tsafrir S. Leket-Mor ,  Bertram Jacobs ,  Lydia Meador ,  Karen Kibler

IPC: A61K39/21 ,  C07K14/16 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K2039/5258 ,  A61K2039/575 ,  C07K14/161 ,  C07K14/162 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234

Abstract: Disclosed are compositions for generating an immune response against human immunodeficiency virus (HIV) and their methods of uses.

公开(公告)号：US20190328864A1

公开(公告)日：2019-10-31

申请号：US16396676

申请日：2019-04-27

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Tsafrir Mor ,  Bertram Jacobs ,  Lydia Meador ,  Karen Kibler

IPC: A61K39/21

Abstract: Disclosed are compositions for generating an immune response against human immunodeficiency virus (HIV) and their methods of uses.

公开(公告)号：US20190183947A1

公开(公告)日：2019-06-20

申请号：US16304564

申请日：2017-05-25

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Bertram Jacobs ,  Heather Koehler ,  William Arndt ,  Karen Kibler ,  Kelly Trainor ,  Chandra Mitnik ,  Jeffrey Langland

IPC: A61K35/768 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K35/768 ,  A61K9/0019 ,  A61K45/06 ,  A61P35/00 ,  C12N7/00 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132

Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.