公开(公告)号：US20230375538A1

公开(公告)日：2023-11-23

申请号：US18017563

申请日：2021-07-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joshua LABAER ,  Jin PARK ,  Femina RAUF

IPC: G01N33/537 ,  G01N33/58

CPC classification number: G01N33/537 ,  G01N33/58 ,  G01N2458/10

Abstract: Provided herein are compositions comprising coordinated sets of unique DNA barcodes and methods for using the same for multiplex detection and measurement of multiple target molecules in multiple samples using a single next-generation sequencing reaction. In particular, methods are provided in which unique DNA barcodes linked to affinity reagents are contacted to a sample to bind antigens if present in said sample, and then a PCR-based amplification reaction adds barcoded index sequences that contain universal sequencing adaptors as well as unique barcode sequences and amplifies affinity reagent-bound targets for DNA sequencing.

公开(公告)号：US20180050038A1

公开(公告)日：2018-02-22

申请号：US15555241

申请日：2016-03-02

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Fernanda FESTA ,  Joshua LABAER ,  Jin PARK ,  Femina RAUF

IPC: A61K31/519 ,  A61K31/517

CPC classification number: A61K31/519 ,  A61K31/517

Abstract: Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method comprises administering to a subject having a disease that exhibits over-activation of the ERBB4 pathway and a gene expression profile consistent with an ERBB4-sensitive profile a therapeutically effective amount of an ERBB4 inhibitor, wherein the disease is effectively treated. Gene expression profiles of ERBB4-sensitive cells and microarrays suitable for protein-tyrosine kinases are also provided.