公开(公告)号：US20170205431A1

公开(公告)日：2017-07-20

申请号：US15479110

申请日：2017-04-04

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: G01N33/68 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/005 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/76 ,  C12N15/1037 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/7047

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20200299367A1

公开(公告)日：2020-09-24

申请号：US16672034

申请日：2019-11-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  C07K16/00 ,  G01N33/68 ,  C12N15/10

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20250084157A1

公开(公告)日：2025-03-13

申请号：US18829906

申请日：2024-09-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  A61K39/00 ,  C07K16/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20210324060A1

公开(公告)日：2021-10-21

申请号：US17327462

申请日：2021-05-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  C07K16/00 ,  G01N33/68 ,  C12N15/10

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US20180298086A1

公开(公告)日：2018-10-18

申请号：US15881392

申请日：2018-01-26

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael SIERKS ,  Huilai TIAN

IPC: C07K16/18 ,  G01N33/68 ,  C12N15/10

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.