公开(公告)号：US20210396745A1

公开(公告)日：2021-12-23

申请号：US17462842

申请日：2021-08-31

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander Green ,  Duo Ma ,  Luhui Shen ,  Chris Diehnelt

IPC: G01N33/543 ,  G01N33/569 ,  C07K19/00 ,  G01N33/53

Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.

公开(公告)号：US12018252B2

公开(公告)日：2024-06-25

申请号：US17711849

申请日：2022-04-01

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Stephen Albert Johnston ,  Luhui Shen

IPC: C12N15/10 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

CPC classification number: C12N15/1062 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K39/0011 ,  A61P35/00 ,  C12N15/1093 ,  G01N33/57484 ,  G01N33/57488

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

公开(公告)号：US11976274B2

公开(公告)日：2024-05-07

申请号：US17706469

申请日：2022-03-28

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Stephen Albert Johnston ,  Luhui Shen

IPC: C12N15/10 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

CPC classification number: C12N15/1062 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K39/0011 ,  A61P35/00 ,  C12N15/1093 ,  G01N33/57484 ,  G01N33/57488

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

公开(公告)号：US11484581B2

公开(公告)日：2022-11-01

申请号：US16617889

申请日：2018-06-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Stephen Albert Johnston ,  Luhui Shen

IPC: A61K39/00 ,  A61P35/00 ,  A61K9/00 ,  G01N33/50 ,  G01N33/574 ,  A61K39/39

Abstract: Provided herein, are methods of treating cancer in dogs using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.

公开(公告)号：US11125743B2

公开(公告)日：2021-09-21

申请号：US16279045

申请日：2019-02-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander Green ,  Duo Ma ,  Luhui Shen ,  Chris Diehnelt

IPC: G01N33/543 ,  G01N33/53 ,  G01N33/569 ,  C07K19/00

Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.

公开(公告)号：US20190285620A1

公开(公告)日：2019-09-19

申请号：US16279045

申请日：2019-02-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander Green ,  Duo Ma ,  Luhui Shen ,  Chris Diehnelt

IPC: G01N33/543 ,  G01N33/569 ,  C07K19/00 ,  G01N33/53

Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.