公开(公告)号：US20160018408A1

公开(公告)日：2016-01-21

申请号：US14773750

申请日：2014-03-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Neal WOODBURY ,  Stephen JOHNSTON ,  Phillip STAFFORD

IPC: G01N33/68

CPC classification number: G01N33/6845

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract translation: 本申请提供了用于这种阵列的免疫标记和质量控制的阵列。 还公开了肽阵列及其用于诊断，治疗和研究的用途。

公开(公告)号：US20200256861A1

公开(公告)日：2020-08-13

申请号：US16562383

申请日：2019-09-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Stephen Albert JOHNSTON ,  Phillip STAFFORD ,  Neal WOODBURY

IPC: G01N33/543 ,  G01N33/68 ,  B82Y15/00 ,  B01J19/00

Abstract: Health is a complex state that represents the continuously changing outcome of nearly all human activities and interactions. The invention provides efficient methods and arrays for health monitoring, diagnosis, treatment, and preventive care. The invention monitors a broad range of identifying molecules from a subject, such as circulating antibodies, and the invention evaluates a pattern of binding of those molecules to a peptide array. The characterization of the pattern of binding of such molecules to a peptide array with the methods of the invention provide a robust measure of a state of health of a subject.

公开(公告)号：US20210223257A1

公开(公告)日：2021-07-22

申请号：US17249863

申请日：2021-03-16

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Phillip STAFFORD ,  Jian ZHANG ,  Luhui SHEN

IPC: G01N33/68 ,  A61K39/00 ,  A61K45/06

Abstract: Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.

公开(公告)号：US20180275136A1

公开(公告)日：2018-09-27

申请号：US15991892

申请日：2018-05-29

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Neal WOODBURY ,  Stephen JOHNSTON ,  Phillip STAFFORD

IPC: G01N33/68

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

公开(公告)号：US20220074946A1

公开(公告)日：2022-03-10

申请号：US17305975

申请日：2021-07-19

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Neal WOODBURY ,  Stephen JOHNSTON ,  Phillip STAFFORD

IPC: G01N33/68

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

公开(公告)号：US20210063409A1

公开(公告)日：2021-03-04

申请号：US16748723

申请日：2020-01-21

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Neal WOODBURY ,  Stephen JOHNSTON ,  Phillip STAFFORD

IPC: G01N33/68

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.