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公开(公告)号：US20170106344A1
公开(公告)日：2017-04-20
申请号：US15264426
申请日：2016-09-13
Inventor： Neal WOODBURY , Zhang-Gong ZHAO
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00432 , B01J2219/00596 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00725 , C07K1/047 , C40B50/18 , C40B80/00
Abstract: Described herein are in situ synthesized arrays and methods of making them, wherein array signal sensitivity and robustness is enhanced by carrying out conditioning steps and/or generating linkers during synthesis. An array comprises a surface with a collection of features, wherein the features comprise molecules or polymers attached to the surface. In certain embodiments of the invention, carrying out conditioning steps during array synthesis can yield arrays with improved signal. In other embodiments, linkers are synthesized on the array surface prior to synthesis of functional molecules, wherein increasing linker length can correspond to an improvement in the signal generated by the array.
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公开(公告)号：US20180275136A1
公开(公告)日：2018-09-27
申请号：US15991892
申请日：2018-05-29
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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3.发明申请公开(公告)号：US20180259510A1
公开(公告)日：2018-09-13
申请号：US15978016
申请日：2018-05-11
Inventor： Neal WOODBURY , Stephen JOHNSTON , Zhan Gong ZHAO , Matthew GREVING
IPC: G01N33/543
CPC classification number: G01N33/54366
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US20220074946A1
公开(公告)日：2022-03-10
申请号：US17305975
申请日：2021-07-19
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US20210063409A1
公开(公告)日：2021-03-04
申请号：US16748723
申请日：2020-01-21
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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Patent Agency Ranking
公开(公告)号：US20240158776A1
公开(公告)日：2024-05-16
申请号：US18481955
申请日：2023-10-05
Inventor： Jinglin FU , Zhao ZHAO , Neal WOODBURY , Hao YAN
Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
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公开(公告)号：US20200256861A1
公开(公告)日：2020-08-13
申请号：US16562383
申请日：2019-09-05
Inventor： Stephen Albert JOHNSTON , Phillip STAFFORD , Neal WOODBURY
IPC: G01N33/543 , G01N33/68 , B82Y15/00 , B01J19/00
Abstract: Health is a complex state that represents the continuously changing outcome of nearly all human activities and interactions. The invention provides efficient methods and arrays for health monitoring, diagnosis, treatment, and preventive care. The invention monitors a broad range of identifying molecules from a subject, such as circulating antibodies, and the invention evaluates a pattern of binding of those molecules to a peptide array. The characterization of the pattern of binding of such molecules to a peptide array with the methods of the invention provide a robust measure of a state of health of a subject.
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公开(公告)号：US20210086159A1
公开(公告)日：2021-03-25
申请号：US17008425
申请日：2020-08-31
Inventor： Neal WOODBURY , Zhang-Gong ZHAO
Abstract: Described herein are in situ synthesized arrays and methods of making them, wherein array signal sensitivity and robustness is enhanced by carrying out conditioning steps and/or generating linkers during synthesis. An array comprises a surface with a collection of features, wherein the features comprise molecules or polymers attached to the surface. In certain embodiments of the invention, carrying out conditioning steps during array synthesis can yield arrays with improved signal. In other embodiments, linkers are synthesized on the array surface prior to synthesis of functional molecules, wherein increasing linker length can correspond to an improvement in the signal generated by the array.
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公开(公告)号：US20200270599A1
公开(公告)日：2020-08-27
申请号：US16812225
申请日：2020-03-06
Inventor： Jinglin FU , Zhao ZHAO , Neal WOODBURY , Hao YAN
Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
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10.发明申请NON-CONVALENT PATTERNED CHEMICAL FEATURES AND USE THEREOF IN MALDI-BASED QUALITY CONTROL 有权非等效图案化学特征及其在基于MALDI的质量控制中的应用公开(公告)号：US20160041158A1
公开(公告)日：2016-02-11
申请号：US14773751
申请日：2014-03-14
Inventor： Neal WOODBURY , Stephen JOHNSTON , Zhan Gong ZHAO , Matthew GREVING
IPC: G01N33/543
CPC classification number: G01N33/54366
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
Abstract translation: 本申请提供了用于这种阵列的免疫标记和质量控制的阵列。 还公开了肽阵列及其用于诊断，治疗和研究的用途。
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