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公开(公告)号：US20220341930A1
公开(公告)日：2022-10-27
申请号：US17806242
申请日：2022-06-09
Inventor： Stephen JOHNSTON , Lu Wang
IPC: G01N33/569
Abstract: Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage.
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公开(公告)号：US20180275136A1
公开(公告)日：2018-09-27
申请号：US15991892
申请日：2018-05-29
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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3.发明申请公开(公告)号：US20180259510A1
公开(公告)日：2018-09-13
申请号：US15978016
申请日：2018-05-11
Inventor： Neal WOODBURY , Stephen JOHNSTON , Zhan Gong ZHAO , Matthew GREVING
IPC: G01N33/543
CPC classification number: G01N33/54366
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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4.发明申请NON-CONVALENT PATTERNED CHEMICAL FEATURES AND USE THEREOF IN MALDI-BASED QUALITY CONTROL 有权非等效图案化学特征及其在基于MALDI的质量控制中的应用公开(公告)号：US20160041158A1
公开(公告)日：2016-02-11
申请号：US14773751
申请日：2014-03-14
Inventor： Neal WOODBURY , Stephen JOHNSTON , Zhan Gong ZHAO , Matthew GREVING
IPC: G01N33/543
CPC classification number: G01N33/54366
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
Abstract translation: 本申请提供了用于这种阵列的免疫标记和质量控制的阵列。 还公开了肽阵列及其用于诊断，治疗和研究的用途。
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公开(公告)号：US20160018408A1
公开(公告)日：2016-01-21
申请号：US14773750
申请日：2014-03-14
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
CPC classification number: G01N33/6845
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
Abstract translation: 本申请提供了用于这种阵列的免疫标记和质量控制的阵列。 还公开了肽阵列及其用于诊断，治疗和研究的用途。
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Patent Agency Ranking
公开(公告)号：US20210164991A1
公开(公告)日：2021-06-03
申请号：US16954187
申请日：2019-01-16
Inventor： Stephen JOHNSTON , Lu WANG
Abstract: A method of inducing a generalized immune response, includes administering to a subject an immunologically effective amount of one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46, thereby inducing a generalized immune response to infection by a pathogen in a subject. A prophylactic or therapeutic composition for inducing a generalized immune response, includes an immunologically effective amount of one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46. A method of distinguishing a subject infected with a pathogen from an uninfected subject, includes detecting an antibody in the subject that selectively binds one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46, wherein the presence of the antibody indicates that the subject is infected with the pathogen. A general method to discover broadly protective components for a vaccine is also disclosed.
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公开(公告)号：US20160153991A1
公开(公告)日：2016-06-02
申请号：US14776434
申请日：2014-03-12
Inventor： Nidhi GUPTA , Chris DIEHNELT , Charles ARNTZEN , Stephen JOHNSTON
IPC: G01N33/569 , C07K14/00
CPC classification number: G01N33/56983 , C07K14/001 , C07K16/08 , C07K2318/20 , G01N2333/08 , G01N2469/10 , G01N2800/26
Abstract: Synbodies specific for Norovirus and coupled with a substrate provide Norovirus binding and detection platforms (FIG. 1). A Norovirus capturing platform, comprising one or more synbodies selected from the group consisting of synbodies 6-6, 92-92, 93-93, and 94-94 coupled to a substrate, has been found to found to bind with either GII.4 Minerva or both GII.4 Minerva and GII.4 Sydney# strains of norovirus.
Abstract translation: 针对诺如病毒特异性并与底物偶联的合成体提供诺如病毒结合和检测平台（图1）。 已经发现包含一个或多个选自偶联于底物的合成体6-6,92-92,93-93和94-94的合成体的诺如病毒捕获平台被发现与GII.4结合 Minerva或GII.4 Minerva和GII.4悉尼＃诺如病毒株。
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公开(公告)号：US20220074946A1
公开(公告)日：2022-03-10
申请号：US17305975
申请日：2021-07-19
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US20210063409A1
公开(公告)日：2021-03-04
申请号：US16748723
申请日：2020-01-21
Inventor： Neal WOODBURY , Stephen JOHNSTON , Phillip STAFFORD
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US20160207984A1
公开(公告)日：2016-07-21
申请号：US14913089
申请日：2014-08-25
Inventor： Christopher DIEHNELT , Nidhi GUPTA , Valeriy DOMENYUK , Zhan-Gong ZHAO , Stephen JOHNSTON
IPC: C07K16/10 , G01N33/569 , C07K14/00
CPC classification number: C07K16/1018 , A61K38/00 , C07K14/001 , C07K14/11 , C07K2318/20 , G01N33/56983 , G01N2333/11 , G01N2469/10
Abstract: Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.
Abstract translation: 结合流感的合成体的组成。 合成体由连接在支架上的两种肽组成。
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