公开(公告)号：US20230250487A1

公开(公告)日：2023-08-10

申请号：US18296915

申请日：2023-04-06

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Rizal HARIADI ,  Hao YAN ,  Swarup DEY

IPC: C12Q1/6886 ,  C12Q1/682 ,  C12Q1/6881

CPC classification number: C12Q1/6886 ,  C12Q1/682 ,  C12Q1/6881 ,  C12Q1/6841 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Disclosed herein are methods and compositions comprising transmembrane nanosensors, and their use to identify, detect, label, and isolate cells. In some embodiments, the nanosensors may be used in conjunction with a hybridization chain reaction to amplify a signal, and to aid in the detection, identification, labeling or isolation of cells.

公开(公告)号：US20250051830A1

公开(公告)日：2025-02-13

申请号：US18700676

申请日：2022-10-12

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Swarup DEY ,  Fei ZHENG

IPC: C12Q1/6825 ,  C12Q1/6818

Abstract: A nanostructure comprising: a) a base plate sheet comprising a single-duplex layer comprised of DNA origami configured in a planar arrangement, b) a pore configured within the center of the base plate sheet, and c) a multi-duplex layer-thick wall comprising a single-duplex layer comprised of DNA origami that extends downward from the base plate sheet on the periphery of the pore, wherein the base plate sheet comprises a single-stranded DNA region on the bottom surface for lipid membrane anchor modification.