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公开(公告)号：US20200079761A1
公开(公告)日：2020-03-12
申请号：US16535931
申请日：2019-08-08
Inventor： Gianni CHESSARI , Steven HOWARD , lldiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mantyla NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00 , C07D413/06 , C07D403/12 , C07F9/572
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20170029419A1
公开(公告)日：2017-02-02
申请号：US15105360
申请日：2014-12-19
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elisabeth WILSHER
IPC: C07D471/04 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20250092027A1
公开(公告)日：2025-03-20
申请号：US18767400
申请日：2024-07-09
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US20180065959A1
公开(公告)日：2018-03-08
申请号：US15675052
申请日：2017-08-11
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20230227450A1
公开(公告)日：2023-07-20
申请号：US18069571
申请日：2022-12-21
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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Patent Agency Ranking
公开(公告)号：US20220204503A1
公开(公告)日：2022-06-30
申请号：US17643083
申请日：2021-12-07
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20200325134A1
公开(公告)日：2020-10-15
申请号：US16795117
申请日：2020-02-19
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20170334907A1
公开(公告)日：2017-11-23
申请号：US15585908
申请日：2017-05-03
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , C07D487/10 , C07D487/04 , C07D471/10 , C07D413/14 , C07D403/14 , A61K31/496 , C07D401/06 , A61K31/5377 , A61K31/506 , A61K31/5025 , A61K31/501 , A61K31/497 , C07D403/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20240199607A1
公开(公告)日：2024-06-20
申请号：US18499940
申请日：2023-11-01
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.-
公开(公告)号：US20210276984A1
公开(公告)日：2021-09-09
申请号：US17164045
申请日：2021-02-01
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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