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公开(公告)号：US20170029419A1
公开(公告)日：2017-02-02
申请号：US15105360
申请日：2014-12-19
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elisabeth WILSHER
IPC: C07D471/04 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20180065959A1
公开(公告)日：2018-03-08
申请号：US15675052
申请日：2017-08-11
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20240199607A1
公开(公告)日：2024-06-20
申请号：US18499940
申请日：2023-11-01
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.-
公开(公告)号：US20210122749A1
公开(公告)日：2021-04-29
申请号：US17034926
申请日：2020-09-28
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , C07D401/06 , C07D471/10 , C07D403/06 , C07D487/10 , C07D403/14 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D487/04 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20150353537A1
公开(公告)日：2015-12-10
申请号：US14436319
申请日：2013-10-18
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Lee William PAGE , Ildiko Maria BUCK , James Edward Harvey DAY , Steven HOWARD , Gordon SAXTY , Christopher William MURRAY
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D403/14 , C07D471/04 , C07D519/00
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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Patent Agency Ranking
公开(公告)号：US20150291586A1
公开(公告)日：2015-10-15
申请号：US14663534
申请日：2015-03-20
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , A61K31/496 , C07D403/14 , C07D471/10 , C07D487/10 , C07D519/00 , C07D413/14 , C07D487/04 , A61K31/5025 , A61K31/506 , A61K31/501 , A61K31/497 , C07D403/06 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20230227450A1
公开(公告)日：2023-07-20
申请号：US18069571
申请日：2022-12-21
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20220204503A1
公开(公告)日：2022-06-30
申请号：US17643083
申请日：2021-12-07
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20200325134A1
公开(公告)日：2020-10-15
申请号：US16795117
申请日：2020-02-19
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Gianni CHESSARI , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Ildiko Maria BUCK , Charlotte Mary GRIFFITHS-JONES , Gordon SAXTY , Emiliano TAMANINI , Nicola Elizabeth WILSHER
IPC: C07D471/04 , A61K31/5377
Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20170334907A1
公开(公告)日：2017-11-23
申请号：US15585908
申请日：2017-05-03
Applicant: ASTEX THERAPEUTICS LIMITED
Inventor： Alison Jo-Anne WOOLFORD , Steven HOWARD , Ildiko Maria BUCK , Gianni CHESSARI , Christopher Norbert JOHNSON , Emiliano TAMANINI , James Edward Harvey DAY , Elisabetta CHIARPARIN , Thomas Daniel HEIGHTMAN , Martyn FREDERICKSON , Charlotte Mary GRIFFITHS-JONES
IPC: C07D471/04 , C07D487/10 , C07D487/04 , C07D471/10 , C07D413/14 , C07D403/14 , A61K31/496 , C07D401/06 , A61K31/5377 , A61K31/506 , A61K31/5025 , A61K31/501 , A61K31/497 , C07D403/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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