公开(公告)号：US20170334907A1

公开(公告)日：2017-11-23

申请号：US15585908

申请日：2017-05-03

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne WOOLFORD ,  Steven HOWARD ,  Ildiko Maria BUCK ,  Gianni CHESSARI ,  Christopher Norbert JOHNSON ,  Emiliano TAMANINI ,  James Edward Harvey DAY ,  Elisabetta CHIARPARIN ,  Thomas Daniel HEIGHTMAN ,  Martyn FREDERICKSON ,  Charlotte Mary GRIFFITHS-JONES

IPC: C07D471/04 ,  C07D487/10 ,  C07D487/04 ,  C07D471/10 ,  C07D413/14 ,  C07D403/14 ,  A61K31/496 ,  C07D401/06 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/501 ,  A61K31/497 ,  C07D403/06 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US20150291586A1

公开(公告)日：2015-10-15

申请号：US14663534

申请日：2015-03-20

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne WOOLFORD ,  Steven HOWARD ,  Ildiko Maria BUCK ,  Gianni CHESSARI ,  Christopher Norbert JOHNSON ,  Emiliano TAMANINI ,  James Edward Harvey DAY ,  Elisabetta CHIARPARIN ,  Thomas Daniel HEIGHTMAN ,  Martyn FREDERICKSON ,  Charlotte Mary GRIFFITHS-JONES

IPC: C07D471/04 ,  A61K31/496 ,  C07D403/14 ,  C07D471/10 ,  C07D487/10 ,  C07D519/00 ,  C07D413/14 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  C07D403/06 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract translation: 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。

公开(公告)号：US20240199607A1

公开(公告)日：2024-06-20

申请号：US18499940

申请日：2023-11-01

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne WOOLFORD ,  Steven HOWARD ,  Ildiko Maria BUCK ,  Gianni CHESSARI ,  Christopher Norbert JOHNSON ,  Emiliano TAMANINI ,  James Edward Harvey DAY ,  Elisabetta CHIARPARIN ,  Thomas Daniel HEIGHTMAN ,  Martyn FREDERICKSON ,  Charlotte Mary GRIFFITHS-JONES

IPC: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I):




or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US20210122749A1

公开(公告)日：2021-04-29

申请号：US17034926

申请日：2020-09-28

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne WOOLFORD ,  Steven HOWARD ,  Ildiko Maria BUCK ,  Gianni CHESSARI ,  Christopher Norbert JOHNSON ,  Emiliano TAMANINI ,  James Edward Harvey DAY ,  Elisabetta CHIARPARIN ,  Thomas Daniel HEIGHTMAN ,  Martyn FREDERICKSON ,  Charlotte Mary GRIFFITHS-JONES

IPC: C07D471/04 ,  C07D401/06 ,  C07D471/10 ,  C07D403/06 ,  C07D487/10 ,  C07D403/14 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/04 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.