公开(公告)号：US11866428B2

公开(公告)日：2024-01-09

申请号：US17034926

申请日：2020-09-28

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne Woolford ,  Steven Howard ,  Ildiko Maria Buck ,  Gianni Chessari ,  Christopher Norbert Johnson ,  Emiliano Tamanini ,  James Edward Harvey Day ,  Elisabetta Chiarparin ,  Thomas Daniel Heightman ,  Martyn Frederickson ,  Charlotte Mary Griffiths-Jones

IPC: C07D471/04 ,  C07D401/06 ,  C07D471/10 ,  C07D403/06 ,  C07D487/10 ,  C07D403/14 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I):




or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US12202828B2

公开(公告)日：2025-01-21

申请号：US18069571

申请日：2022-12-21

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Steven Howard ,  James Edward Harvey Day ,  Ildiko Maria Buck ,  Charlotte Mary Griffiths-Jones ,  Gordon Saxty ,  Emiliano Tamanini ,  Nicola Elizabeth Wilsher

IPC: C07D471/04 ,  A61K31/5377

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US09617248B2

公开(公告)日：2017-04-11

申请号：US14436319

申请日：2013-10-18

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Lee William Page ,  Ildiko Maria Buck ,  James Edward Harvey Day ,  Steven Howard ,  Gordon Saxty ,  Christopher William Murray

IPC: C07D403/14 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D403/14 ,  C07D471/04 ,  C07D519/00

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US09783538B2

公开(公告)日：2017-10-10

申请号：US15105360

申请日：2014-12-19

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Steven Howard ,  James Edward Harvey Day ,  Ildiko Maria Buck ,  Charlotte Mary Griffiths-Jones ,  Gordon Saxty ,  Emiliano Tamanini ,  Nicola Elisabeth Wilsher

IPC: C07D471/04 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/5377

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US09676768B2

公开(公告)日：2017-06-13

申请号：US14663534

申请日：2015-03-20

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Alison Jo-Anne Woolford ,  Steven Howard ,  Ildiko Maria Buck ,  Gianni Chessari ,  Christopher Norbert Johnson ,  Emiliano Tamanini ,  James Edward Harvey Day ,  Elisabetta Chiarparin ,  Thomas Daniel Heightman ,  Martyn Frederickson ,  Charlotte Mary Griffiths-Jones

IPC: A61K31/497 ,  A61K31/501 ,  C07D403/04 ,  C07D419/00 ,  C07D471/04 ,  C07D401/06 ,  C07D471/10 ,  C07D403/06 ,  C07D487/10 ,  C07D403/14 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00

Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US11643410B2

公开(公告)日：2023-05-09

申请号：US17643083

申请日：2021-12-07

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Steven Howard ,  James Edward Harvey Day ,  Ildiko Maria Buck ,  Charlotte Mary Griffiths-Jones ,  Gordon Saxty ,  Emiliano Tamanini ,  Nicola Elizabeth Wilsher

IPC: C07D471/04 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/5377

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US11225476B2

公开(公告)日：2022-01-18

申请号：US16795117

申请日：2020-02-19

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Steven Howard ,  James Edward Harvey Day ,  Ildiko Maria Buck ,  Charlotte Mary Griffiths-Jones ,  Gordon Saxty ,  Emiliano Tamanini ,  Nicola Elizabeth Wilsher

IPC: C07D471/04 ,  A61K31/5377

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US09617283B2

公开(公告)日：2017-04-11

申请号：US14436345

申请日：2013-10-18

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Lee William Page ,  Ildiko Maria Buck ,  James Edward Harvey Day ,  Steven Howard ,  Gordon Saxty ,  Christopher William Murray ,  Anna Hopkins

IPC: C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D519/00 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

公开(公告)号：US20150259359A1

公开(公告)日：2015-09-17

申请号：US14436345

申请日：2013-10-18

Applicant: ASTEX THERAPEUTICS LIMITED

Inventor： Gianni Chessari ,  Christopher Norbert Johnson ,  Lee William Page ,  Ildiko Maria Buck ,  James Edward Harvey Day ,  Steven Howard ,  Gordon Saxty ,  Christopher William Murray ,  Anna Hopkins

IPC: C07D519/00 ,  C07D487/04 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.