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公开(公告)号：US11866428B2
公开(公告)日：2024-01-09
申请号：US17034926
申请日：2020-09-28
发明人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号： C07D471/04 , C07D401/06 , C07D471/10 , C07D403/06 , C07D487/10 , C07D403/14 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5025 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.-
公开(公告)号：US12071429B2
公开(公告)日：2024-08-27
申请号：US17164045
申请日：2021-02-01
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
CPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/5728 , C07B2200/05
摘要： The invention provides a compound of formula (I):
or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US10981898B2
公开(公告)日：2021-04-20
申请号：US16535931
申请日：2019-08-08
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US11261171B1
公开(公告)日：2022-03-01
申请号：US16680969
申请日：2019-11-12
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D401/06 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4545 , A61K31/444 , A61K31/4439 , A61P35/00 , C07D417/14 , C07D409/14 , C07D407/14 , C07D403/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D487/04 , C07B59/00 , C07D487/08 , A61K45/06
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US09783538B2
公开(公告)日：2017-10-10
申请号：US15105360
申请日：2014-12-19
发明人： Gianni Chessari , Christopher Norbert Johnson , Steven Howard , James Edward Harvey Day , Ildiko Maria Buck , Charlotte Mary Griffiths-Jones , Gordon Saxty , Emiliano Tamanini , Nicola Elisabeth Wilsher
IPC分类号： C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/5377
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US09676768B2
公开(公告)日：2017-06-13
申请号：US14663534
申请日：2015-03-20
发明人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号： A61K31/497 , A61K31/501 , C07D403/04 , C07D419/00 , C07D471/04 , C07D401/06 , C07D471/10 , C07D403/06 , C07D487/10 , C07D403/14 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US10544132B2
公开(公告)日：2020-01-28
申请号：US15763698
申请日：2016-09-29
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US09663512B2
公开(公告)日：2017-05-30
申请号：US14436364
申请日：2013-10-18
发明人： Gianni Chessari , Christopher Norbert Johnson , Lee William Page , Alessia Millemaggi , Steven Howard , Gordon Saxty , Thomas Daniel Heightman
IPC分类号： C07D471/04 , C07D403/14 , C07D519/00 , C07D487/04
CPC分类号： C07D471/04 , C07D403/14 , C07D487/04 , C07D519/00
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US09617248B2
公开(公告)日：2017-04-11
申请号：US14436319
申请日：2013-10-18
发明人： Gianni Chessari , Christopher Norbert Johnson , Lee William Page , Ildiko Maria Buck , James Edward Harvey Day , Steven Howard , Gordon Saxty , Christopher William Murray
IPC分类号： C07D403/14 , C07D471/04 , C07D519/00
CPC分类号： C07D403/14 , C07D471/04 , C07D519/00
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20150266873A1
公开(公告)日：2015-09-24
申请号：US14436364
申请日：2013-10-18
发明人： Gianni Chessari , Christopher Norbert Johnson , Lee William Page , Alessia Millemaggi , Steven Howard , Gordon Saxty , Thomas Daniel Heightman
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D403/14 , C07D487/04 , C07D519/00
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的双环杂环化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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