公开(公告)号：US20170136450A1

公开(公告)日：2017-05-18

申请号：US15039189

申请日：2014-09-10

申请人： Asymchem Laboratories (Tianjin) Co., Ltd. ,  Asymchem Life Science (Tianjin) Co., Ltd. ,  Tianjin Asymchem Pharmaceutical Co., Ltd. ,  Asymchem Laboratories (Fuxin) Co., Ltd. ,  Jilin Asymchem Laboratories Co., Ltd.

发明人： Hao HONG ,  Jiuyuan LI ,  Changming DONG ,  Xin ZHANG ,  Gage JAMES

IPC分类号： B01J31/06 ,  B01J31/28 ,  C07D477/04 ,  C08J9/00 ,  C08J9/14 ,  C08F212/08

CPC分类号： B01J31/06 ,  B01J23/464 ,  B01J31/28 ,  C07D477/04 ,  C07D477/06 ,  C08F12/22 ,  C08F12/26 ,  C08F12/32 ,  C08F12/34 ,  C08F212/08 ,  C08F212/14 ,  C08J9/0061 ,  C08J9/141 ,  C08J9/142 ,  C08J9/145 ,  C08J9/149 ,  C08J2203/12 ,  C08J2203/14 ,  C08J2203/142 ,  C08J2325/08 ,  C08J2405/00 ,  C08J2429/04 ,  Y02P20/584 ,  C08F212/34 ,  C08F212/36 ,  C08F212/32

摘要： A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.

公开(公告)号：US20220297080A1

公开(公告)日：2022-09-22

申请号：US17642194

申请日：2019-09-12

申请人： ASYMCHEM LABORATORIES (FUXIN) CO., LTD.

发明人： Hao HONG ,  Jiangping LU ,  Xichun FENG ,  Xin ZHANG ,  Bo YAN

IPC分类号： B01J19/18 ,  C07C41/54 ,  C07C45/50 ,  C07C45/64

摘要： The present disclosure provides a device for continuously preparing 2,6-dihydroxybenzaldehyde and use thereof. The device includes a first continuous reaction unit for hydroxy protection reaction, a second continuous reaction unit for lithiation and hydroformylation, and a third continuous reaction unit for deprotection reaction that are connected in series. The third continuous reaction unit includes: a first columnar continuous reactor, connected to the second continuous reaction unit and used for deprotection of the lithiated hydroformylated product while performing liquid separation to obtain an organic phase containing 2,6-dihydroxybenzaldehyde and an aqueous phase. When the device is applied in the preparation of 2,6-dihydroxybenzaldehyde, reaction time is shortened and the intermediate purification treatment is no longer required. Therefore, compared with batch process, the present disclosure can greatly save equipment cost and post-processing cost, and greatly improve the production efficiency, more beneficial to the industrial scale-up production of 2,6-dihydroxybenzaldehyde.