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公开(公告)号：US20200377485A1
公开(公告)日：2020-12-03
申请号：US16061557
申请日：2016-12-16
IPC分类号： C07D405/14 , A61P23/00
摘要： The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20170065585A1
公开(公告)日：2017-03-09
申请号：US15348091
申请日：2016-11-10
发明人： Giuseppe ALVARO , Anne DECOR , Stefano FONTANA , Dieter HAMPRECHT , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译： 本发明提供式（Ia）化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途，以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症，例如抑郁症 情绪障碍，听觉障碍，分裂症，药物滥用障碍，睡眠障碍或癫痫。
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公开(公告)号：US20160251340A1
公开(公告)日：2016-09-01
申请号：US15093004
申请日：2016-04-07
发明人： Giuseppe ALVARO , Paolo DAMBRUOSO , Simona TOMMASI , Anne DECOR , Charles LARGE , Agostino MARASCO
IPC分类号： C07D405/12 , C07D307/79 , C07D307/94
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/79 , C07D307/94 , C07D317/46 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20200163964A1
公开(公告)日：2020-05-28
申请号：US16777668
申请日：2020-01-30
发明人： Giuseppe ALVARO , Anne DECOR , Stefano FONTANA , Dieter HAMPRECHT , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4166 , C07D233/72 , C07D239/47 , C07D239/22 , C07D403/04 , C07D401/04 , C07D233/76
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
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公开(公告)号：US20190192516A1
公开(公告)日：2019-06-27
申请号：US16285996
申请日：2019-02-26
发明人： Giuseppe ALVARO , Paolo DAMBRUOSO , Simona TOMMASI , Anne DECOR , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/506 , C07D317/46 , C07D405/14 , C07D307/94 , A61K31/4439 , C07D413/14 , C07D413/12 , C07D405/12 , C07D307/79
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/79 , C07D307/94 , C07D317/46 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20180021336A1
公开(公告)日：2018-01-25
申请号：US15722623
申请日：2017-10-02
发明人： Giuseppe ALVARO , Anne DECOR , Stefano FONTANA , Dieter HAMPRECHT , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/506 , C07D401/04 , C07D403/04 , C07D233/76 , A61K31/4439 , C07D239/22 , C07D233/72
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
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公开(公告)号：US20170273981A1
公开(公告)日：2017-09-28
申请号：US15621400
申请日：2017-06-13
发明人： Giuseppe ALVARO , Paolo DAMBRUOSO , Simona TOMMASI , Anne DECOR , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/506 , C07D413/14 , C07D405/12 , A61K31/4439 , C07D317/46 , C07D413/12 , C07D405/14 , C07D307/94 , C07D307/79
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/79 , C07D307/94 , C07D317/46 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20160058737A1
公开(公告)日：2016-03-03
申请号：US14935939
申请日：2015-11-09
发明人： Giuseppe ALVARO , Anne DECOR , Stefano FONTANA , Dieter HAMPRECHT , Charles LARGE , Agostino MARASCO
IPC分类号： A61K31/4166 , A61K31/506 , A61K31/4439
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译： 本发明提供式（Ia）化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途，以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症，例如抑郁症 情绪障碍，听觉障碍，分裂症，药物滥用障碍，睡眠障碍或癫痫。
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