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公开(公告)号：US11147813B2
公开(公告)日：2021-10-19
申请号：US16060714
申请日：2016-12-09
发明人： Charles Large , Giuseppe Alvaro
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4196 , C07C43/315 , C07D307/94 , A61P29/02 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof: (I).
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公开(公告)号：US10555945B2
公开(公告)日：2020-02-11
申请号：US16125148
申请日：2018-09-07
发明人： Giuseppe Alvaro , Agostino Marasco
IPC分类号： A61K31/506 , C07D413/12 , C07D405/12 , C07D413/14 , C07D307/79 , C07D307/94 , C07D405/14 , C07D317/46 , A61K31/4439
摘要： The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20190161479A1
公开(公告)日：2019-05-30
申请号：US16321742
申请日：2017-07-28
发明人： Giuseppe ALVARO , Agostino MARASCO , Guido MARCONI
IPC分类号： C07D405/12 , A61P25/00 , C07D207/333 , C07D307/94 , C07D491/107
摘要： The present invention provides compounds of the formula (I) and their use as Kv3 modulators.
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公开(公告)号：US10160730B2
公开(公告)日：2018-12-25
申请号：US15208329
申请日：2016-07-12
发明人： Agostino Marasco , Giuseppe Alvaro , Anne Dècor , Dieter Hamprecht , Paolo Dambruoso , Simona Tommasi
IPC分类号： C07D405/14 , C07D249/12 , C07D307/94 , C07D311/04 , C07D311/76 , C07D311/96 , C07D401/04 , C07D307/87 , C07C43/313 , C07C255/46 , C07C43/29 , C07C255/37 , C07C43/225 , C07C255/48
摘要： Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
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公开(公告)号：US09849131B2
公开(公告)日：2017-12-26
申请号：US15348091
申请日：2016-11-10
发明人： Giuseppe Alvaro , Anne Decor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号： A61K31/506 , C07D233/76 , C07D401/04 , C07D403/04 , C07D239/22 , C07D239/47 , C07D233/72 , A61K31/4166 , A61K31/4439 , C07D213/643
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
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公开(公告)号：US09669030B2
公开(公告)日：2017-06-06
申请号：US14403011
申请日：2013-05-22
发明人： Charles Large
IPC分类号： A61K31/506 , C07D405/14 , C07D307/94 , C07D311/76 , C07D401/04 , C07D403/04 , C07D405/12 , C07D307/87 , A61K31/4439
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/87 , C07D307/94 , C07D311/76 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14
摘要： The present invention relates to the prophylaxis of acute noise-induced hearing loss by administering a compound of formula (I): wherein: W is group (Wa), group (Wb) or group (Wc):
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公开(公告)号：US20150336936A1
公开(公告)日：2015-11-26
申请号：US14816476
申请日：2015-08-03
发明人： Giuseppe ALVARO , Agostino MARASCO
IPC分类号： C07D405/12 , C07D307/79 , C07D317/46 , C07D307/94
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/79 , C07D307/94 , C07D317/46 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： Compounds of formula (I): are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or treatment of related disorders.
摘要翻译： 式（I）化合物：在此描述。 本公开的化合物是Kv3通道的调节剂，可用于预防或治疗相关疾病。
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公开(公告)号：US11180461B2
公开(公告)日：2021-11-23
申请号：US16785083
申请日：2020-02-07
发明人： Agostino Marasco , Giuseppe Alvaro , Anne Dècor , Dieter Hamprecht , Paolo Dambruoso , Simona Tommasi
IPC分类号： C07D405/14 , C07D249/12 , C07D307/94 , C07D311/04 , C07D311/76 , C07D311/96 , C07D401/04 , C07D307/87 , C07C43/313 , C07C255/46 , C07C43/29 , C07C255/37 , C07C43/225 , C07C255/48 , C07D405/04
摘要： Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
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公开(公告)号：US20190000849A1
公开(公告)日：2019-01-03
申请号：US16125148
申请日：2018-09-07
发明人： Giuseppe ALVARO , Agostino MARASCO
IPC分类号： A61K31/506 , A61K31/4439 , C07D317/46 , C07D405/14 , C07D405/12 , C07D307/79 , C07D413/14 , C07D413/12 , C07D307/94
CPC分类号： A61K31/506 , A61K31/4439 , C07D307/79 , C07D307/94 , C07D317/46 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US10098881B2
公开(公告)日：2018-10-16
申请号：US15730559
申请日：2017-10-11
发明人： Giuseppe Alvaro , Agostino Marasco
IPC分类号： C07D405/14 , C07D413/14 , A61K31/506 , C07D405/12 , C07D413/12 , C07D307/79 , C07D307/94 , C07D317/46 , A61K31/4439
摘要： Methods for the treatment of Fragile X that includes administering to a subject in need thereof a compound of formula (I): are described herein.
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