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公开(公告)号：US20080171704A1
公开(公告)日：2008-07-17
申请号：US11999208
申请日：2007-12-04
申请人： Aaron I. Vinik , Lawrence Rosenberg , Gary Pittenger , David Taylor-Fishwick , Michael Salem , Scott Mohrland
发明人： Aaron I. Vinik , Lawrence Rosenberg , Gary Pittenger , David Taylor-Fishwick , Michael Salem , Scott Mohrland
CPC分类号： C07K14/474 , A61K38/00 , C07K14/4733
摘要： The present invention comprises dosing regimens and formulations of islet cell neogenesis associated protein (INGAP) and INGAP Peptide. The formulation disclosed herein is shown have acceptable stability as a pharmaceutical composition. Further, the formulation is able to regenerate functional islets.
摘要翻译： 本发明包括胰岛细胞新生相关蛋白（INGAP）和INGAP肽的给药方案和制剂。 本文公开的制剂显示具有作为药物组合物的可接受的稳定性。 此外，制剂能够再生功能性胰岛。
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公开(公告)号：US5840531A
公开(公告)日：1998-11-24
申请号：US709662
申请日：1996-09-09
IPC分类号： A01K67/027 , A61K31/70 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P3/08 , A61P43/00 , C07K14/47 , C07K14/52 , C07K16/24 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/566 , C12N15/00
CPC分类号： C07K14/474 , C07K14/4733 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
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公开(公告)号：US5834590A
公开(公告)日：1998-11-10
申请号：US401530
申请日：1995-02-22
CPC分类号： C07K14/4733 , C07K14/474 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
摘要翻译： 仓鼠胰腺的玻璃纸包裹（CW）诱导管道上皮细胞的增殖，随后内分泌细胞分化和胰岛新生。 使用mRNA差异显示技术鉴定了在包装但不在对照胰腺中的玻璃纸中表达的cDNA克隆。 使用该cDNA作为探针，筛选cDNA文库，鉴定未描述的基因并命名为INGAP。
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公开(公告)号：US5804421A
公开(公告)日：1998-09-08
申请号：US909725
申请日：1997-08-12
IPC分类号： C12N15/09 , C07K1/22 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12N15/00
CPC分类号： C07K14/4733 , C07K2319/00
摘要： Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
摘要翻译： 从INGAP编码序列去除编码信号肽的核苷酸序列使得培养的细胞能够表达大量的INGAP活性。 以前的尝试只提供了低产量的INGAP，可能是因为INGAP的信号序列对细胞有毒性。
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公开(公告)号：US07442774B2
公开(公告)日：2008-10-28
申请号：US11244524
申请日：2005-10-06
IPC分类号： G01N33/53
CPC分类号： C07K14/474 , C07K14/4733 , G01N33/6854 , Y10T436/105831 , Y10T436/11
摘要： An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
摘要翻译： 提供特异性识别和结合INGAP蛋白的抗体。 该抗体用于生物样品中INGAP定量的竞争性结合测定。 该测定可以在固体支持物或悬浮液中进行。
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公开(公告)号：US07166439B2
公开(公告)日：2007-01-23
申请号：US10376046
申请日：2003-02-27
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N2333/4733 , G01N2333/474 , G01N2410/00
摘要： A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
摘要翻译： 使用固相测定法检测作为胰岛新生相关蛋白（INGAP）的生物活性部分的15个氨基酸肽的INGAP 104-118肽的抗体。 可以测定INGAP 104-118肽抗体的同种型。 试剂盒也可用于检测抗INGAP 104-118抗体。 可以监测具有INGAP 104-118的哺乳动物的治疗性治疗期间的内源性自身抗体或抗体产生。
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公开(公告)号：US06986994B2
公开(公告)日：2006-01-17
申请号：US10036418
申请日：2002-01-07
IPC分类号： G01N33/53
CPC分类号： C07K14/474 , C07K14/4733 , G01N33/6854 , Y10T436/105831 , Y10T436/11
摘要： An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
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8.发明申请公开(公告)号：US20120058078A1
公开(公告)日：2012-03-08
申请号：US13195596
申请日：2011-08-01
IPC分类号： A61K38/20 , G01N27/447 , G01N33/559 , C12Q1/34 , A61P43/00
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof.
摘要翻译： 报道构建体含有哺乳动物INGAP5调控区或其片段，来自哺乳动物INGAP或异源启动子的最小启动子元件和报告基因。 报道构建体可用于筛选单独或组合上调或下调报告基因表达的试剂。 或者，报道构建体可用于筛选结合仓鼠INGAP 5'-调节区或其片段的试剂。
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9.发明申请公开(公告)号：US20090156458A1
公开(公告)日：2009-06-18
申请号：US12062740
申请日：2008-04-04
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof.
摘要翻译： 报道构建体含有哺乳动物INGAP5调控区或其片段，来自哺乳动物INGAP或异源启动子的最小启动子元件和报告基因。 报道构建体可用于筛选单独或组合上调或下调报告基因表达的试剂。 或者，报道构建体可用于筛选结合仓鼠INGAP 5'-调节区或其片段的试剂。
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10.发明授权Regulatory sequences for modulation of INGAP expression and reporter constructs 失效用于调节INGAP表达和报道构建体的调控序列公开(公告)号：US07355024B2
公开(公告)日：2008-04-08
申请号：US10339767
申请日：2003-01-09
IPC分类号： C07H21/04
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A an isolated mammalian INGAP 5″-regulatory region comprising at least about nucleotides 1-3137 of SEQ ID NO: 2 (SEQ ID NO: 23).
摘要翻译： 分离的哺乳动物INGAP 5“调节区，其包含至少约SEQ ID NO：2的核苷酸1-3137（SEQ ID NO：23）。
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