公开(公告)号：US20080051672A1

公开(公告)日：2008-02-28

申请号：US11925657

申请日：2007-10-26

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

IPC分类号： A61B5/0402

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20050197674A1

公开(公告)日：2005-09-08

申请号：US10795126

申请日：2004-03-05

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

IPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/375 ,  A61N1/362

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20110022109A1

公开(公告)日：2011-01-27

申请号：US12893127

申请日：2010-09-29

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61N1/365 ,  A61N1/375

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US07818051B2

公开(公告)日：2010-10-19

申请号：US11925657

申请日：2007-10-26

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US07299086B2

公开(公告)日：2007-11-20

申请号：US10795126

申请日：2004-03-05

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/0428 ,  A61N1/368

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20120053474A1

公开(公告)日：2012-03-01

申请号：US13288105

申请日：2011-11-03

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/0452 ,  A61N1/365

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗器械表面上的电极的各种组合。

公开(公告)号：US20050288600A1

公开(公告)日：2005-12-29

申请号：US10876008

申请日：2004-06-24

申请人： Yi Zhang ,  Marina Brockway ,  Carlos Ricci ,  Ron Heil ,  Douglas Daum ,  Robert Sweeney ,  Aaron McCabe

发明人： Yi Zhang ,  Marina Brockway ,  Carlos Ricci ,  Ron Heil ,  Douglas Daum ,  Robert Sweeney ,  Aaron McCabe

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/042 ,  A61N1/365 ,  A61N1/375 ,  G06K9/62

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3756 ,  G06K9/624

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。 信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。 信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。 如果需要或必要，可以更新所选择的向量。 信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。 分离可以包括主成分分析和/或独立成分分析。 可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

公开(公告)号：US09138590B2

公开(公告)日：2015-09-22

申请号：US13535104

申请日：2012-06-27

申请人： Yi Zhang ,  Aaron McCabe ,  David J. Yonce ,  Julie Thompson

发明人： Yi Zhang ,  Aaron McCabe ,  David J. Yonce ,  Julie Thompson

IPC分类号： A61N1/372 ,  A61N1/39 ,  A61N1/362 ,  A61N1/37 ,  A61N1/375 ,  A61N1/08

CPC分类号： A61N1/3956 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/686 ,  A61N1/3622 ,  A61N1/3706 ,  A61N1/3712 ,  A61N1/3756 ,  A61N1/3925 ,  A61N2001/083

摘要： A CRM system enhances intracardiac electrogram-based arrhythmia detection using a wireless electrocardiogram (ECG), which is a signal sensed with implantable electrodes and approximating a surface ECG. In one embodiment, an intracardiac electrogram allows for detection of an arrhythmia, and the wireless ECG allows for classification of the detected arrhythmia by locating its origin. In another embodiment, the wireless ECG is sensed as a substitute signal for the intracardiac electrogram when the sensing of the intracardiac electrogram becomes unreliable. In another embodiment, a cardiac signal needed for a particular purpose is selected from one or more intracardiac electrograms and one or more wireless ECGs based on a desirable signal quality. In another embodiment, intracardiac electrogram-based arrhythmia detection and wireless ECG-based arrhythmia detection confirm with each other before indicating a detection of arrhythmia of a certain type.

摘要翻译： CRM系统使用无线心电图（ECG）来增强基于心脏电图的心律失常检测，无线心电图（ECG）是用可植入电极感测并近似表面ECG的信号。 在一个实施例中，心内电描记图允许检测心律失常，并且无线ECG允许通过定位其起点来分类检测到的心律失常。 在另一个实施例中，当心脏电图的感测变得不可靠时，无线ECG被感测为心内电描记图的替代信号。 在另一个实施例中，基于期望的信号质量，从一个或多个心内电描记图和一个或多个无线ECG选择特定目的所需的心脏信号。 在另一个实施例中，基于心脏电图的心律失常检测和基于无线ECG的心律失常检测在指示某种类型的心律失常的检测之前相互确认。

公开(公告)号：US20120303082A1

公开(公告)日：2012-11-29

申请号：US13306611

申请日：2011-11-29

申请人： Yanting Dong ,  Shibaji Shome ,  Aaron McCabe ,  Amy J. Brisben ,  Clayton Foster ,  David W. Yost ,  Kenneth N. Hayes

发明人： Yanting Dong ,  Shibaji Shome ,  Aaron McCabe ,  Amy J. Brisben ,  Clayton Foster ,  David W. Yost ,  Kenneth N. Hayes

IPC分类号： A61N1/37 ,  A61N1/365

CPC分类号： A61N1/371 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/4836 ,  A61B5/7217 ,  A61B5/7267 ,  A61N1/3712

摘要： Discrimination between different types of possible cardiac pacing responses may depend on the timing of expected features that are sensed within a temporal framework. The temporal framework may include classification intervals, blanking periods and appropriately timed back up paces. The classification intervals and blanking periods of the temporal framework are intervals of time that have time parameters that include start time, end time, and length. The relationships and timing parameters of the elements of the temporal framework, e.g., blanking periods, classification intervals, delay periods, and backup pacing, should support detection of features used to discriminate between different types of pacing responses. As the system learns the morphology of the particular patient by analyzing the waveform of the pacing response signal, the temporal framework for pacing response determination may be adjusted to accommodate the individual patient.

摘要翻译： 不同类型的可能心脏起搏反应之间的歧视可能取决于在时间框架内感测到的预期特征的时间。 时间框架可以包括分类间隔，消隐期和适当定时的后台步数。 时间框架的分类间隔和消隐期是具有包括开始时间，结束时间和长度的时间参数的时间间隔。 时间框架的元素的关系和定时参数，例如消隐期，分类间隔，延迟周期和备份起搏应该支持用于区分不同类型的起搏响应的特征的检测。 当系统通过分析起搏响应信号的波形来学习特定患者的形态时，可调整起搏响应确定的时间框架以适应个体患者。

公开(公告)号：US20110106199A1

公开(公告)日：2011-05-05

申请号：US12986762

申请日：2011-01-07

申请人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。