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公开(公告)号:US09031650B2
公开(公告)日:2015-05-12
申请号:US12986762
申请日:2011-01-07
申请人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
CPC分类号: A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译: 本主题的各个方面涉及一种方法。 根据各种方法实施例,检测心脏活动,并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。
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公开(公告)号:US20130197594A1
公开(公告)日:2013-08-01
申请号:US13798684
申请日:2013-03-13
申请人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/36
CPC分类号: A61N1/36114 , A61N1/36053 , A61N1/3606 , A61N1/36128 , A61N1/36139
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
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公开(公告)号:US08406876B2
公开(公告)日:2013-03-26
申请号:US12688575
申请日:2010-01-15
申请人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron R. McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/365
CPC分类号: A61N1/36114 , A61N1/36053 , A61N1/3606 , A61N1/36128 , A61N1/36139
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
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公开(公告)号:US20110106199A1
公开(公告)日:2011-05-05
申请号:US12986762
申请日:2011-01-07
申请人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/365
CPC分类号: A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译: 本主题的各个方面涉及一种方法。 根据各种方法实施例,检测心脏活动,并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。
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公开(公告)号:US07873413B2
公开(公告)日:2011-01-18
申请号:US11459481
申请日:2006-07-24
申请人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/36
CPC分类号: A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译: 本主题的各个方面涉及一种方法。 根据各种方法实施例,检测心脏活动,并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。
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公开(公告)号:US20080021504A1
公开(公告)日:2008-01-24
申请号:US11459481
申请日:2006-07-24
申请人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/36
CPC分类号: A61N1/36139 , A61N1/36114 , A61N1/36135 , A61N1/365 , A61N1/36592 , A61N1/3962 , A61N1/3987
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译: 本主题的各个方面涉及一种方法。 根据各种方法实施例,检测心脏活动,并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。
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公开(公告)号:US20100121399A1
公开(公告)日:2010-05-13
申请号:US12688575
申请日:2010-01-15
申请人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
发明人: Aaron McCabe , Imad Libbus , Yi Zhang , Paul A. Haefner , Alok S. Sathaye , Anthony V. Caparso , M. Jason Brooke
IPC分类号: A61N1/365
CPC分类号: A61N1/36114 , A61N1/36053 , A61N1/3606 , A61N1/36128 , A61N1/36139
摘要: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译: 本主题的各个方面涉及一种方法。 根据各种方法实施例,检测心脏活动,并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。
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公开(公告)号:US08442635B2
公开(公告)日:2013-05-14
申请号:US13031762
申请日:2011-02-22
IPC分类号: A61N1/08
CPC分类号: A61N1/37282 , A61N1/368 , A61N1/3684 , A61N1/3706 , A61N2001/083
摘要: This document discusses, among other things, systems and methods for automatic electrode integrity management. Interelectrode impedance is measured for various electrode combinations of an implantable cardiac function management device. The impedance data is processed, such as at an external remote server, to determine whether an electrode is failing or has failed, to select an alternate electrode configuration, to alert a physician or patient, to predict a time-to-failure such as by using population data, or to reprogram electrode configuration or other device parameters of the implantable cardiac function management device.
摘要翻译: 本文件还讨论了自动电极完整性管理的系统和方法。 测量可植入心脏功能管理装置的各种电极组合的电极内阻抗。 处理阻抗数据,例如在外部远程服务器处,以确定电极是否发生故障或失败,选择备用电极配置,以警告医师或患者预测失效时间,例如通过 使用种群数据,或重新编程可植入心脏功能管理装置的电极配置或其他装置参数。
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公开(公告)号:US07797050B2
公开(公告)日:2010-09-14
申请号:US12691392
申请日:2010-01-21
申请人: Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人: Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号: A61N1/00
CPC分类号: A61N1/36185 , A61N1/3611
摘要: Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译: 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器,适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器,以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍,并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经,各种实施方案刺激复发性喉神经,并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。
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公开(公告)号:US08560072B2
公开(公告)日:2013-10-15
申请号:US13596595
申请日:2012-08-28
申请人: Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人: Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号: A61N1/18
CPC分类号: A61N1/3601 , A61N1/36114
摘要: A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译: 提供了一种用于呼吸神经控制的系统,装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例,该装置包括感测电路,用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器,以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中,该装置包括多个传感器,其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。
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